Osaterone acetate
Osaterone acetate (OSA) is a synthetic steroidal antiandrogen and progestin. It is primarily used in veterinary medicine for the treatment of benign prostatic hyperplasia (BPH) in dogs. Osaterone acetate is structurally related to cyproterone acetate and has similar pharmacological properties.
Pharmacology
Osaterone acetate works by inhibiting the effects of androgens (male sex hormones) such as testosterone and dihydrotestosterone (DHT). It competes with androgens for binding to the androgen receptor and also reduces the production of androgens by inhibiting the enzyme 5α-reductase, which converts testosterone to the more potent DHT. Additionally, osaterone acetate has progestogenic activity, which contributes to its antiandrogenic effects.
Veterinary Use
Osaterone acetate is used in veterinary medicine to treat benign prostatic hyperplasia (BPH) in male dogs. BPH is a common condition in older male dogs, characterized by an enlarged prostate gland, which can lead to urinary and defecatory difficulties. By reducing the size of the prostate gland, osaterone acetate alleviates these symptoms.
Administration and Dosage
Osaterone acetate is administered orally, typically in the form of tablets. The dosage and duration of treatment depend on the severity of the condition and the response to therapy. It is important to follow the veterinarian's instructions carefully to ensure the effectiveness and safety of the treatment.
Side Effects
Common side effects of osaterone acetate in dogs may include:
- Increased appetite
- Weight gain
- Lethargy
- Behavioral changes
Less common but more serious side effects can include:
- Liver dysfunction
- Adrenal suppression
Related Compounds
Osaterone acetate is chemically related to other steroidal antiandrogens and progestins, such as cyproterone acetate and chlormadinone acetate. These compounds share similar mechanisms of action and therapeutic uses.
See Also
References
External Links
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