Osaterone acetate
Osaterone acetate (OSA) is a synthetic steroidal antiandrogen and progestin. It is primarily used in veterinary medicine for the treatment of benign prostatic hyperplasia (BPH) in dogs. Osaterone acetate is structurally related to cyproterone acetate and has similar pharmacological properties.
Pharmacology[edit]
Osaterone acetate works by inhibiting the effects of androgens (male sex hormones) such as testosterone and dihydrotestosterone (DHT). It competes with androgens for binding to the androgen receptor and also reduces the production of androgens by inhibiting the enzyme 5α-reductase, which converts testosterone to the more potent DHT. Additionally, osaterone acetate has progestogenic activity, which contributes to its antiandrogenic effects.
Veterinary Use[edit]
Osaterone acetate is used in veterinary medicine to treat benign prostatic hyperplasia (BPH) in male dogs. BPH is a common condition in older male dogs, characterized by an enlarged prostate gland, which can lead to urinary and defecatory difficulties. By reducing the size of the prostate gland, osaterone acetate alleviates these symptoms.
Administration and Dosage[edit]
Osaterone acetate is administered orally, typically in the form of tablets. The dosage and duration of treatment depend on the severity of the condition and the response to therapy. It is important to follow the veterinarian's instructions carefully to ensure the effectiveness and safety of the treatment.
Side Effects[edit]
Common side effects of osaterone acetate in dogs may include:
- Increased appetite
- Weight gain
- Lethargy
- Behavioral changes
Less common but more serious side effects can include:
- Liver dysfunction
- Adrenal suppression
Related Compounds[edit]
Osaterone acetate is chemically related to other steroidal antiandrogens and progestins, such as cyproterone acetate and chlormadinone acetate. These compounds share similar mechanisms of action and therapeutic uses.
See Also[edit]
References[edit]
External Links[edit]
-
 | This medical article is a stub. You can help WikiMD by expanding the page. |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
