16-Ketoestrone
16-Ketoestrone
16-Ketoestrone is a metabolite of the estrogen hormone estrone. It is one of the many metabolites that are formed during the metabolism of estrogens in the human body. The study of estrogen metabolites like 16-Ketoestrone is important for understanding their roles in various physiological and pathological processes.
Chemical Structure
16-Ketoestrone is characterized by the presence of a keto group at the 16th position of the estrone molecule. This modification alters the biological activity of the compound compared to its parent hormone, estrone. The chemical structure of 16-Ketoestrone is depicted in the adjacent image.
Biological Role
As a metabolite of estrone, 16-Ketoestrone is involved in the complex network of estrogen metabolism. Estrogens are crucial for the regulation of the menstrual cycle, reproductive system, and secondary sexual characteristics. The metabolism of estrogens, including the formation of 16-Ketoestrone, can influence their biological activity and impact health.
Clinical Significance
The levels of 16-Ketoestrone and other estrogen metabolites can be measured in biological fluids and may provide insights into various health conditions. Abnormal levels of estrogen metabolites have been associated with conditions such as breast cancer, endometriosis, and osteoporosis. Understanding the metabolism of estrogens, including the formation of 16-Ketoestrone, is important for developing therapeutic strategies and diagnostic tools.
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