Androstadienol

Androstadienol is a naturally occurring steroid and a member of the androgen family. It is a derivative of androstadienone, which is a well-known pheromone found in humans. Androstadienol is characterized by its chemical structure, 5,16-androstadien-3_-ol, and plays a role in the modulation of olfactory signals and pheromone activity.

Chemical Structure

Androstadienol is a steroid with the molecular formula C₁₉H₂₈O. It features a hydroxyl group at the 3_ position and double bonds at the 5 and 16 positions of the androstane skeleton. This structure is crucial for its biological activity and interaction with olfactory receptors.

Biological Role

Androstadienol is involved in the pheromone signaling pathways in humans. It is believed to influence social behavior and sexual attraction through its effects on the olfactory system. The compound is thought to be a precursor to other active pheromones, such as androstadienone, which have been studied for their effects on mood and endocrine responses.

Synthesis and Metabolism

In the human body, androstadienol is synthesized from cholesterol through a series of enzymatic reactions. It is metabolized in the liver and other tissues, where it can be converted into other biologically active steroids. The metabolism of androstadienol is part of the broader steroidogenesis pathway, which produces various androgens and estrogens.

Applications

Research into androstadienol and related compounds is ongoing, with interest in their potential applications in perfumes and fragrances due to their pheromone-like properties. Additionally, there is interest in their use in clinical settings to modulate mood and behavior in certain psychiatric conditions.

Related Pages

• Androstadienone
• Pheromone
• Steroid
• Androgen
• Olfactory system

• 

  5,16-androstadien-3β-ol