Glutethimide

Glutethimide is a hypnotic sedative that was introduced by Ciba in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similarly severe withdrawal symptoms.

Pharmacology

Glutethimide is a sedative and hypnotic. It acts on the central nervous system (CNS) to produce its sedative effects. Glutethimide is metabolized by the liver and its metabolites are excreted in the urine.

Medical Uses

Glutethimide is used for the short-term treatment of insomnia. It is also used as an adjunct in the treatment of anxiety disorders and for the management of epilepsy.

Side Effects

Common side effects of glutethimide include dizziness, drowsiness, headache, nausea, and vomiting. More serious side effects can include confusion, hallucinations, and severe allergic reactions.

Addiction and Withdrawal

Like other sedatives, glutethimide can cause physical and psychological dependence. Withdrawal symptoms can be severe and include anxiety, restlessness, and insomnia.

Interactions

Glutethimide can interact with other medications, including other CNS depressants, certain antibiotics, and certain antifungal medications.

Contraindications

Glutethimide is contraindicated in patients with known hypersensitivity to the drug, in patients with severe respiratory disease, and in patients with acute intermittent porphyria.

See Also

• Sedative
• Hypnotic
• Insomnia
• Anxiety
• Epilepsy

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  Chemical structure of Glutethimide
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  Ball-and-stick model of Glutethimide
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  Glutethimide tablets seized by the Department of Justice
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  Synthesis pathway of Glutethimide