Ovandrotone albumin

Ovandrotone albumin is a protein that is encoded by the OVA gene in humans. It is a member of the serpin family of proteins, which are involved in various biological processes such as coagulation, complement activation, fibrinolysis, angiogenesis, inflammation, and tumor suppression.

Etymology

The term "Ovandrotone" is derived from the Latin "ovum", meaning "egg", and "andro", meaning "man". The "tone" suffix indicates that it is a type of hormone. The term "albumin" is derived from the Latin "albus", meaning "white", and refers to the color of the protein in its pure form.

Function

Ovandrotone albumin is a serine protease inhibitor (serpin) that functions as a tumor suppressor by inhibiting the activity of certain proteases that are involved in cancer progression. It is also involved in the regulation of angiogenesis, the process by which new blood vessels are formed from pre-existing ones.

Clinical significance

Mutations in the OVA gene can lead to the development of various types of cancer, including ovarian cancer, breast cancer, and lung cancer. In addition, overexpression of ovandrotone albumin has been associated with poor prognosis in patients with these types of cancer.

See also

• Serpin
• Protease
• Angiogenesis
• Tumor suppressor

References

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