Acolbifene

From WikiMD's medical encyclopedia

Acolbifene structure

Acolbifene (INN), with developmental code names EM-652 and SCH-57068, is a nonsteroidal selective estrogen receptor modulator (SERM). As of 2015, it was in advanced stages of clinical testing for its potential application in the treatment of breast cancer.

Pharmacology

Mechanism of Action

Acolbifene operates as a selective estrogen receptor modulator (SERM). SERMs are a group of compounds that bind to estrogen receptors in the body. Depending on the tissue type, they can either inhibit or activate estrogen-like actions. In the context of breast cancer, Acolbifene is expected to inhibit the estrogenic stimulation of cancer cells, potentially limiting the growth and proliferation of such cells.

Development

Pre-clinical Studies

Prior to advancing to human trials, Acolbifene underwent extensive pre-clinical testing. These tests aimed to determine its pharmacological properties, potential therapeutic benefits, and safety profile.

Clinical Trials

By 2015, Acolbifene had progressed to phase III clinical trials. This phase of clinical testing evaluates the drug's effectiveness, monitors side effects, and compares it to commonly used treatments for the targeted condition, in this case, breast cancer.

Potential Therapeutic Use

Breast Cancer Treatment

Breast cancer remains one of the most prevalent forms of cancer globally. The potential application of Acolbifene in its treatment is of significant interest to the medical community. Given its mechanism of action, Acolbifene could offer an alternative or supplemental approach to current breast cancer treatments, especially for cases driven by estrogenic stimulation.

See Also

External links

Estrogens and antiestrogens
Estrogens
ER agonists
* Steroidal: Alfatradiol
Progonadotropins
Antiestrogens
ER 
antagonists
(incl. SERMs

/SERDs

)
Aromatase inhibitors
* First-generation: Aminoglutethimide
Antigonadotropins
Others
* Mixed mechanism of action: Danazol


Estrogen receptor modulators
ER
Agonists
* Steroidal: 2-Hydroxyestradiol
Mixed
(SERMs )
* 2-Phenylbenzofuran
Antagonists
GPER
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Contributors: Prab R. Tumpati, MD