16α-Hydroxyestrone
Metabolite of estrone
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16α-Hydroxyestrone (16α-OH-E1) is a metabolite of the estrogen estrone. It is formed through the hydroxylation of estrone at the C16α position. This compound is one of the many estrogen metabolites that can be found in the human body.
Biological Role
16α-Hydroxyestrone is known to exhibit estrogenic activity, although its potency is generally lower than that of estradiol. It is involved in various physiological processes and has been studied for its potential role in breast cancer and other hormone-related cancers. Elevated levels of 16α-Hydroxyestrone have been associated with an increased risk of developing certain types of cancer.
Metabolism
The metabolism of 16α-Hydroxyestrone involves its formation from estrone via the action of specific cytochrome P450 enzymes. It can be further metabolized into other compounds, including estriol and 16α-hydroxyestradiol.
Clinical Significance
The measurement of 16α-Hydroxyestrone levels can be used as a biomarker for assessing the risk of hormone-related cancers. It is also of interest in the study of endocrine disorders and the effects of hormone replacement therapy.
See Also
References
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