Potassium canrenoate
A potassium-sparing diuretic used in medicine
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Potassium canrenoate is a potassium-sparing diuretic that is used in the treatment of conditions such as heart failure, hypertension, and edema. It is a prodrug of canrenone, which acts as an aldosterone antagonist.
Pharmacology
Potassium canrenoate works by inhibiting the effects of aldosterone, a hormone that promotes the retention of sodium and water in the body. By blocking aldosterone, potassium canrenoate helps to increase the excretion of sodium and water while retaining potassium, thus acting as a diuretic.
Mechanism of Action
Potassium canrenoate is converted in the body to its active form, canrenone. Canrenone competes with aldosterone for receptor sites in the distal convoluted tubule and collecting duct of the nephron, reducing sodium reabsorption and increasing potassium retention.
Clinical Uses
Potassium canrenoate is primarily used in the management of conditions where fluid retention is a problem, such as:
- Congestive heart failure
- Cirrhosis of the liver with ascites
- Nephrotic syndrome
- Hypertension
Side Effects
Common side effects of potassium canrenoate include:
- Hyperkalemia (elevated potassium levels)
- Hyponatremia (low sodium levels)
- Gynecomastia
- Gastrointestinal disturbances
Contraindications
Potassium canrenoate should not be used in patients with:
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