Nitrazepam

Nitrazepam is a type of benzodiazepine drug. It is marketed under several brand names, such as Alodorm, Arem, Insoma, Mogadon, Nitrados, Nitrazadon, Nitrosun, Ormodon, Paxadorm, Remnos, and Somnite.

Pharmacology

Nitrazepam is a long-acting benzodiazepine with potent hypnotic properties. It works by enhancing the effect of the neurotransmitter GABA in the brain, resulting in sedative, sleep-inducing, anxiolytic, anticonvulsant, and muscle relaxant effects.

Medical uses

Nitrazepam is primarily used for the short-term treatment of insomnia. It is also used to manage epilepsy and is prescribed for severe, disabling, or distressing conditions.

Side effects

Common side effects of nitrazepam include drowsiness, hypotonia, ataxia, and confusion. Less common side effects include changes in libido, tremor, and gastrointestinal disturbances. Long-term use of nitrazepam can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.

Interactions

Nitrazepam may interact with other medications, including other benzodiazepines, opioids, antipsychotics, and alcohol. These interactions can increase the sedative effects of nitrazepam and may lead to respiratory depression, coma, or death.

See also

• Benzodiazepine
• Insomnia
• Epilepsy

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Nitrazepam

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  Chemical structure of Nitrazepam

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  3D model of Nitrazepam

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  Nitrazepam 5mg tablets (Mogadon)

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  Synthesis of Nitrazepam