16β-Hydroxyestrone

16beta-hydroxyestrone.svg

Metabolite of estrone

16β-Hydroxyestrone is an endogenous estrogen metabolite of estrone. It is formed through the hydroxylation of estrone at the 16β position. This compound is part of the estrogen metabolism pathway and plays a role in the biological activity of estrogens in the body.

Biochemistry

16β-Hydroxyestrone is produced from estrone by the action of specific enzymes known as hydroxylases. These enzymes add a hydroxyl group (-OH) to the 16β position of the estrone molecule. The hydroxylation process is a crucial step in the metabolism of estrogens, influencing their biological activity and excretion.

Function

As a metabolite of estrone, 16β-Hydroxyestrone retains some estrogenic activity, although it is generally less potent than its precursor. It can bind to estrogen receptors and exert effects on various target tissues, including the breast, uterus, and bone. The balance and levels of different estrogen metabolites, including 16β-Hydroxyestrone, are important for maintaining hormonal health and can influence the risk of hormone-related diseases.

Clinical Significance

The levels of 16β-Hydroxyestrone and other estrogen metabolites can be measured to assess hormonal status and metabolic health. Abnormal levels of these metabolites may be associated with various health conditions, including breast cancer, endometrial cancer, and osteoporosis. Understanding the metabolism of estrogens and the role of specific metabolites like 16β-Hydroxyestrone is important for developing targeted therapies and diagnostic tools.

See also

• Estrone
• Estrogen metabolism
• Hydroxylation
• Estrogen receptor
• Hormone-related diseases

References

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