4-Methoxyestradiol
4-Methoxyestradiol (4-MeO-E2) is a synthetic, nonsteroidal estrogen and a derivative of estradiol, the primary female sex hormone. It is characterized by the presence of a methoxy group at the fourth position of the estradiol molecule.
Chemical Structure and Properties
4-Methoxyestradiol is a methoxy derivative of estradiol, specifically modified at the C4 position. The chemical structure of 4-Methoxyestradiol can be represented as follows:
- IUPAC name: (8R,9S,13S,14S,17S)-3-Methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-17,18-diol
- Molecular formula: C19H26O3
- Molecular weight: 302.41 g/mol
Pharmacology
4-Methoxyestradiol exhibits estrogenic activity by binding to and activating the estrogen receptors (ERs), which are intracellular receptors that mediate the effects of estrogens. The binding affinity of 4-Methoxyestradiol to ERs is lower compared to estradiol, but it still exerts significant biological effects.
Biological Effects
As an estrogenic compound, 4-Methoxyestradiol influences various physiological processes, including:
- Regulation of the menstrual cycle
- Development and maintenance of female secondary sexual characteristics
- Modulation of bone density
- Influence on cardiovascular health
Clinical Applications
4-Methoxyestradiol has been studied for its potential therapeutic applications, particularly in the context of hormone replacement therapy (HRT) and the treatment of menopausal symptoms. However, its clinical use is limited, and it is not widely prescribed.
Research and Development
Ongoing research is exploring the potential of 4-Methoxyestradiol in various medical fields, including its role in cancer treatment, particularly breast cancer and endometrial cancer. Its effects on bone health and cardiovascular disease are also areas of active investigation.
See Also
References
External Links
-
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
