Allopregnanolone
Chemical structure of Allopregnanolone
3D ball model of Allopregnanolone
Chorley cake and Eccles cake
Allopregnanolone
Allopregnanolone is a neurosteroid that is derived from the hormone progesterone. It is known for its role in modulating the central nervous system and has been implicated in various physiological and pathological processes.
Structure and Synthesis
Allopregnanolone is a metabolite of progesterone, synthesized in the body through a series of enzymatic reactions. The conversion of progesterone to allopregnanolone involves the action of the enzyme 5_-reductase, which reduces progesterone to 5_-dihydroprogesterone, followed by the action of 3_-hydroxysteroid dehydrogenase to produce allopregnanolone.
Mechanism of Action
Allopregnanolone acts primarily as a positive allosteric modulator of the GABA_A receptor, which is the major inhibitory neurotransmitter receptor in the brain. By enhancing the effects of gamma-aminobutyric acid (GABA), allopregnanolone increases inhibitory neurotransmission, leading to its sedative, anxiolytic, and anticonvulsant effects.
Physiological Roles
Allopregnanolone plays a significant role in the regulation of mood, stress response, and neuroprotection. It is involved in the modulation of anxiety, depression, and stress. During pregnancy, levels of allopregnanolone increase significantly, contributing to the regulation of mood and the prevention of seizures.
Clinical Significance
Allopregnanolone has been studied for its potential therapeutic effects in various conditions, including premenstrual dysphoric disorder (PMDD), postpartum depression, and epilepsy. It is also being investigated for its neuroprotective properties in neurodegenerative diseases such as Alzheimer's disease.
Pharmacology
As a neurosteroid, allopregnanolone can cross the blood-brain barrier and exert its effects directly on the brain. Its pharmacological profile includes sedative, anxiolytic, and anticonvulsant properties, making it a compound of interest for the development of new therapeutic agents.
Related Pages
| Neurosteroids | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
This neurosteroids related article is a stub.
|
| Hormones | ||
|---|---|---|
|
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD
