CSPG5

CSPG5 (Chondroitin Sulfate Proteoglycan 5), also known as Neuroglycan C or NGC, is a protein that in humans is encoded by the CSPG5 gene. It is a member of the proteoglycan family, a group of proteins that are heavily glycosylated. The basic proteoglycan unit consists of a core protein with one or more covalently attached glycosaminoglycan (GAG) chain(s).

Function

CSPG5 is a chondroitin sulfate proteoglycan with a speculated role in the development and plasticity of the nervous system. It is expressed in the brain and other neural tissues, and its expression is upregulated during neuronal differentiation.

Clinical Significance

Alterations in CSPG5 have been associated with neurological disorders. For example, mutations in the CSPG5 gene have been linked to neurodegenerative diseases such as Alzheimer's disease.

Structure

The CSPG5 protein is composed of a core protein and a chondroitin sulfate chain. The core protein has a molecular weight of approximately 150 kDa and is composed of several domains, including a glycosaminoglycan attachment region, a serine/threonine-rich region, and a C-type lectin-like domain.

See Also

• Proteoglycan
• Chondroitin sulfate
• Neuroglycan C
• Gene
• Protein