Icotinib
Icotinib (pronounced as i-koh-tin-ib) is a type of drug that is used in the treatment of certain types of cancer, specifically non-small cell lung cancer. It is classified as an Epidermal Growth Factor Receptor (EGFR) inhibitor, which means it works by blocking the action of a protein in the body that stimulates cancer cell growth.
Etymology
The name "Icotinib" is derived from the International Union of Pure and Applied Chemistry (IUPAC) nomenclature. It is a combination of parts of the words "isoquinoline", "cyano", and "benzene", which refer to the chemical structure of the drug.
Usage
Icotinib is used to treat patients with advanced non-small cell lung cancer who have previously received at least one chemotherapy regimen. It is particularly effective in patients whose tumors have certain types of EGFR mutations.
Mechanism of Action
Icotinib works by binding to the ATP-binding site of the EGFR, thereby inhibiting the activation of the receptor and the subsequent signal transduction pathways that lead to DNA synthesis and cell proliferation.
Related Terms
- Chemotherapy
- Non-small cell lung cancer
- Epidermal Growth Factor Receptor
- Mutation
- ATP-binding site
- DNA synthesis
- Cell proliferation
Side Effects
Like all drugs, Icotinib can cause side effects. Common side effects include skin rash, diarrhea, and liver problems. More serious side effects can include lung problems and eye problems.
See Also
External links
- Medical encyclopedia article on Icotinib
- Wikipedia's article - Icotinib
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