Flutoprazepam

From WikiMD's medical encyclopedia

A benzodiazepine derivative used as a hypnotic and anxiolytic


Chemical structure of Flutoprazepam

Flutoprazepam is a benzodiazepine derivative that is primarily used for its hypnotic and anxiolytic properties. It is a medication that acts on the central nervous system to produce a calming effect, making it useful in the treatment of anxiety and insomnia.

Pharmacology

Flutoprazepam works by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, which is a major inhibitory neurotransmitter in the brain. This action results in increased neuronal inhibition and produces the sedative and anxiolytic effects characteristic of benzodiazepines.

Medical Uses

Flutoprazepam is prescribed for the short-term management of severe anxiety and insomnia. It is particularly useful in situations where rapid onset of action is required. Due to its potential for dependence and tolerance, it is generally recommended for short-term use only.

Side Effects

Common side effects of flutoprazepam include drowsiness, dizziness, and muscle weakness. More serious side effects can include respiratory depression, confusion, and ataxia. Long-term use can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.

Legal Status

The legal status of flutoprazepam varies by country. In some regions, it is classified as a controlled substance due to its potential for abuse and dependence. It is important for prescribers to be aware of the legal regulations regarding its use in their respective countries.

Chemistry

Ball-and-stick model of Flutoprazepam

Flutoprazepam is chemically classified as a benzodiazepine, characterized by its diazepine ring fused to a benzene ring. The presence of a fluorine atom in its structure distinguishes it from other benzodiazepines, contributing to its unique pharmacological profile.

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Contributors: Prab R. Tumpati, MD