Lofendazam

Lofendazam structure

Lofendazam is an organic molecule classified under the benzodiazepine derivatives. A specific kind of benzodiazepine known as a 1,5-benzodiazepine, its uniqueness lies in the placement of nitrogen atoms at the 1 and 5 positions of the diazepine ring. Such a configuration closely aligns it with other 1,5-benzodiazepines, the most notable of which is clobazam^[1].

Chemical Structure and Classification

The realm of benzodiazepines is vast and varied. Within it, 1,5-benzodiazepines form a distinct subclass, defined by the unique placement of their nitrogen atoms. Lofendazam, as a member of this group, not only shares structural similarities with its kin but also exhibits pharmacological properties that differentiate it from other benzodiazepines^[2].

Pharmacological Actions

Like its benzodiazepine counterparts, lofendazam manifests sedative and anxiolytic effects. Such traits make it a viable candidate for the treatment of conditions such as anxiety disorders, sleep disturbances, and certain epileptic forms^[3].

Metabolic Relationship with Arfendazam

Lofendazam's intrigue extends beyond its primary functions. It also acts as an active metabolite for another benzodiazepine named arfendazam. As arfendazam undergoes metabolic breakdown in the body, lofendazam emerges as one of its products, which in turn augments arfendazam's therapeutic influence^[4].

References

↑ Oelschläger H. (2004). Chemical and pharmacologic aspects of benzodiazepines. Schweiz Rundsch Med Prax, 93(30), 1179-86.
↑ Lüllmann, H., Mohr, K., & Hein, L. (2000). Color atlas of pharmacology. Stuttgart: Thieme.
↑ Riss, J., Cloyd, J., Gates, J., & Collins, S. (2008). Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurologica Scandinavica, 118(2), 69-86.
↑ Griffiths, R. R., & Johnson, M. W. (2005). Relative abuse liability of hypnotic drugs: A conceptual framework and algorithm for differentiating among compounds. The Journal of Clinical Psychiatry, 66(suppl 9), 31-41.

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[1] Oelschläger H. (2004). Chemical and pharmacologic aspects of benzodiazepines. Schweiz Rundsch Med Prax, 93(30), 1179-86.

[2] Lüllmann, H., Mohr, K., & Hein, L. (2000). Color atlas of pharmacology. Stuttgart: Thieme.

[3] Riss, J., Cloyd, J., Gates, J., & Collins, S. (2008). Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurologica Scandinavica, 118(2), 69-86.

[4] Griffiths, R. R., & Johnson, M. W. (2005). Relative abuse liability of hypnotic drugs: A conceptual framework and algorithm for differentiating among compounds. The Journal of Clinical Psychiatry, 66(suppl 9), 31-41.

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