Flufenamic acid

Flufenamic acid is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to treat pain and inflammation associated with various conditions, including arthritis, menstrual pain, and muscle sprains and strains.

Chemistry

Flufenamic acid is a white crystalline powder with the chemical formula C14H10F3NO2. It is slightly soluble in water and freely soluble in most organic solvents. The compound is a derivative of anthranilic acid, and its structure includes a trifluoromethyl group, which contributes to its anti-inflammatory activity.

Pharmacology

Flufenamic acid works by inhibiting the production of prostaglandins, chemicals in the body that cause inflammation and pain. It does this by blocking the action of an enzyme called cyclooxygenase (COX), which is involved in the production of prostaglandins. Flufenamic acid is a non-selective COX inhibitor, meaning it blocks both COX-1 and COX-2 enzymes.

Clinical use

Flufenamic acid is used to relieve pain and reduce inflammation in a variety of conditions. It is particularly effective in treating symptoms of rheumatoid arthritis and osteoarthritis, as well as menstrual pain. The drug is usually taken orally, in the form of tablets or capsules.

Side effects

Like other NSAIDs, flufenamic acid can cause a range of side effects. These can include gastrointestinal problems such as stomach ulcers and bleeding, as well as kidney and liver damage in some cases. It can also cause allergic reactions in some people.

See also

• Fenamate
• Nonsteroidal anti-inflammatory drug
• Cyclooxygenase

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