Nisterime

Overview

Nisterime is a pharmaceutical drug used primarily in the treatment of hypertension and certain types of cardiac arrhythmias. It belongs to the class of medications known as calcium channel blockers, which function by inhibiting the influx of calcium ions into cardiac muscle and smooth muscle cells, leading to a decrease in vascular resistance and myocardial contractility.

Mechanism of Action

Nisterime works by blocking the L-type calcium channels in the heart and blood vessels. This action results in the relaxation of vascular smooth muscle, leading to vasodilation and a subsequent reduction in blood pressure. In the heart, it decreases the force of contraction and slows down the heart rate, which can be beneficial in treating arrhythmias.

Clinical Uses

Nisterime is primarily indicated for:

• Hypertension: It helps in lowering high blood pressure, thereby reducing the risk of stroke, myocardial infarction, and kidney damage.
• Angina pectoris: By reducing the workload on the heart, it helps alleviate chest pain associated with angina.
• Arrhythmias: It is used in the management of certain types of cardiac arrhythmias, such as supraventricular tachycardia.

Side Effects

Common side effects of Nisterime include:

• Dizziness
• Headache
• Flushing
• Peripheral edema
• Fatigue

Less common but more serious side effects can include:

• Bradycardia
• Hypotension
• Heart failure

Contraindications

Nisterime should not be used in patients with:

• Severe hypotension
• Cardiogenic shock
• Severe aortic stenosis
• Known hypersensitivity to the drug

Pharmacokinetics

Nisterime is well absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. It is primarily excreted in the urine as inactive metabolites. The drug has a half-life of approximately 6 to 8 hours, necessitating multiple doses throughout the day for sustained therapeutic effect.

Related pages

• Calcium channel blocker
• Hypertension
• Cardiac arrhythmia
• Vasodilation

Chemical structure of Nisterime