Metribolone
Metribolone (also known as methyltrienolone or R1881) is a potent, non-aromatizable androgen that is used in scientific research and has been sold online as a designer steroid. Metribolone is an oral steroid and is one of the strongest available on the market, it is also one of the most hepatotoxic and is not recommended for practical use.
History
Metribolone was first described in 1965. It was immediately recognized as an extraordinarily potent anabolic agent, significantly more potent than the reference anabolic steroid in that study, fluoxymesterone. However, its potential for liver toxicity was also quickly realized.
Pharmacology
As an AAS, metribolone is an agonist of the androgen receptor (AR), similarly to androgens like testosterone and dihydrotestosterone (DHT). It is one of the most potent AAS to have ever been synthesized, with 120–300 times the oral anabolic potency and 60–70 times the androgenic potency of methyltestosterone, and 12 times the oral anabolic potency and 2.5 times the androgenic potency of oxymetholone.
Side Effects
Metribolone is considered one of the most toxic steroids. It is both highly hepatotoxic and capable of causing damage to the liver. It also has potential side effects in many other areas, including cardiovascular complications, and potential direct neurological and mental changes. It is so dangerous that it is often used in research studies to induce damage to the liver as it is so reliably toxic.
Legal Status
In the United States, metribolone is classified as a Schedule III controlled substance under federal regulation, under the Controlled Substances Act. It is also banned by many sporting organizations, including the International Olympic Committee.
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