Spirobarbital
| Spirobarbital | |
|---|---|
| Spirobarbital.svg | |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Spirobarbital is a barbiturate derivative that has been used primarily as a sedative and hypnotic agent. It is known for its central nervous system depressant effects, which make it effective in inducing sleep and reducing anxiety.
Chemical Structure[edit]
Spirobarbital is characterized by its unique chemical structure, which includes a spiro linkage. This structure is responsible for its pharmacological properties and its classification as a barbiturate.
Pharmacology[edit]
Spirobarbital acts on the gamma-aminobutyric acid (GABA) receptor, enhancing the inhibitory effects of GABA in the central nervous system. This action results in sedation, hypnosis, and anxiolysis. Like other barbiturates, it can cause respiratory depression and coma in overdose situations.
Medical Uses[edit]
Spirobarbital has been used in the treatment of insomnia and anxiety disorders. It is effective in inducing sleep and calming patients, but its use is limited due to the potential for dependence and tolerance.
Side Effects[edit]
Common side effects of spirobarbital include drowsiness, dizziness, and headache. Long-term use can lead to physical dependence and withdrawal symptoms upon discontinuation.
History[edit]
Spirobarbital was developed in the early 20th century as part of the search for effective sedative-hypnotic agents. It was used clinically for several decades before being largely replaced by benzodiazepines and other newer agents with improved safety profiles.
Related pages[edit]
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
