2-Hydroxyestradiol
2-Hydroxyestradiol
2-Hydroxyestradiol (pronounced as two-hydroxy-estra-diol) is a naturally occurring estrogen metabolite. It is produced in the body from estradiol, the primary female sex hormone, through the action of the enzyme cytochrome P450 1A1.
Etymology
The term "2-Hydroxyestradiol" is derived from its chemical structure. The "2-Hydroxy" part refers to the presence of a hydroxyl group (-OH) at the 2nd carbon position of the estradiol molecule. "Estradiol" is derived from "estra-", from the Greek "oistros" meaning "gadfly" or "frenzy", and "-diol", a chemical term indicating the presence of two alcohol (-OH) groups.
Function
2-Hydroxyestradiol has been found to have antioxidant properties, which can help protect cells from damage. It is also involved in the regulation of estrogen receptor activity and may play a role in the development and progression of certain types of cancer.
Related Terms
- Estradiol: The parent compound from which 2-Hydroxyestradiol is derived.
- Estrogen: A group of hormones that play an important role in the normal sexual and reproductive development in women.
- Cytochrome P450 1A1: The enzyme responsible for the conversion of estradiol to 2-Hydroxyestradiol.
- Estrogen receptor: A protein within cells that binds to estrogen, triggering a response.
External links
- Medical encyclopedia article on 2-Hydroxyestradiol
- Wikipedia's article - 2-Hydroxyestradiol
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