Cloroqualone

Cloroqualone.svg

Cloroqualone is a quinazolinone class GABAergic drug that was developed in the 1980s. It is structurally related to methaqualone, a well-known sedative and hypnotic medication. Cloroqualone was primarily used for its anxiolytic, sedative, and muscle relaxant properties.

Pharmacology

Cloroqualone acts as a positive allosteric modulator of the GABA_A receptor, which enhances the inhibitory effects of GABA in the central nervous system. This action results in its sedative and anxiolytic effects. The drug also has antihistamine properties, contributing to its sedative effects.

Medical Uses

Cloroqualone was used in the treatment of anxiety disorders, insomnia, and as a muscle relaxant. However, due to its potential for abuse and the development of safer alternatives, its use has declined significantly.

Side Effects

Common side effects of cloroqualone include drowsiness, dizziness, and headache. In higher doses, it can cause respiratory depression, hypotension, and coma. Long-term use can lead to tolerance and dependence.

Legal Status

Due to its potential for abuse and addiction, cloroqualone is classified as a controlled substance in many countries. Its production and distribution are strictly regulated.

History

Cloroqualone was developed in the 1980s as an alternative to methaqualone. However, due to similar issues with abuse and dependence, it did not gain widespread acceptance and was eventually phased out in favor of other medications with better safety profiles.

See Also

• Methaqualone
• GABA_A receptor
• Sedative
• Anxiolytic
• Muscle relaxant