Bifluranol

From WikiMD's medical encyclopedia

Overview of the drug Bifluranol


Bifluranol is a nonsteroidal antiandrogen (NSAA) that was developed for the treatment of prostate cancer. It is a member of the flutamide family of drugs, which are known for their ability to block the effects of androgens like testosterone in the body.

Mechanism of Action

Bifluranol works by inhibiting the action of androgens at the androgen receptors. Androgens are male sex hormones that play a key role in the development and maintenance of male characteristics. In conditions like prostate cancer, androgens can promote the growth of cancer cells. By blocking these hormones, Bifluranol helps to slow down or stop the growth of cancer cells.

Chemical Structure

Bifluranol is chemically related to other nonsteroidal antiandrogens. Its structure allows it to bind to androgen receptors, preventing natural androgens from exerting their effects. This binding is competitive, meaning Bifluranol competes with natural androgens for receptor sites.

Uses

Bifluranol is primarily used in the treatment of prostate cancer. It may be used alone or in combination with other treatments such as surgery, radiation therapy, or other hormonal therapies.

Side Effects

As with other antiandrogens, Bifluranol can cause a range of side effects. Common side effects include:

Pharmacokinetics

The pharmacokinetics of Bifluranol involve its absorption, distribution, metabolism, and excretion. It is typically administered orally and is absorbed through the gastrointestinal tract. The drug is metabolized in the liver and excreted primarily through the urine.

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Contributors: Prab R. Tumpati, MD