Tetrazepam

Tetrazepam is a benzodiazepine derivative with anxiolytic, anticonvulsant, muscle relaxant and slightly hypnotic properties. It was patented in 1962 by Hoffmann-La Roche, a Swiss multinational healthcare company, and has been in medical use since 1965. Tetrazepam is used primarily in the treatment of severe muscle spasms, including those associated with conditions such as tetanus or cerebral palsy.

Pharmacology

Tetrazepam, like other benzodiazepines, works by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, leading to sedative and muscle-relaxant effects. It is metabolized in the body to diazepam, oxazepam, and temazepam, all of which have similar pharmacological effects.

Medical uses

Tetrazepam is used for the treatment of stiff-man syndrome, muscle cramps, and spasticity. It is also used in the treatment of some types of epilepsy and insomnia. In addition, it is used as a premedication before surgical procedures to reduce anxiety and tension.

Side effects

The most common side effects of tetrazepam are drowsiness, fatigue, and muscle weakness. Less common side effects include confusion, depression, and changes in libido. As with other benzodiazepines, there is a risk of dependence and withdrawal symptoms with prolonged use.

Legal status

Tetrazepam is a controlled substance in many countries, including the United States, where it is classified as a Schedule IV controlled substance under the Controlled Substances Act. In the European Union, it was withdrawn from the market in 2013 due to concerns about serious skin reactions.

See also

• Benzodiazepine
• Muscle relaxant
• Anxiolytic

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  Tetrazepam chemical structure

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  3D model of Tetrazepam

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  Epikutanni test