Mibolerone
Mibolerone is a synthetic anabolic steroid and a potent androgen that was developed in the 1960s. It is a derivative of nandrolone and is known for its strong anabolic and androgenic effects. Mibolerone is primarily used in veterinary medicine to prevent estrus (heat) in female dogs.
Chemical Structure and Properties[edit]
Mibolerone is chemically known as 7α,17α-dimethyl-19-nortestosterone. It is a 17α-alkylated derivative of nandrolone, which makes it orally active. The compound has a high affinity for the androgen receptor, contributing to its potent effects.
Medical Uses[edit]
In veterinary medicine, mibolerone is used to suppress estrus in female dogs. It is administered orally and is effective in preventing the onset of heat. The drug is not approved for use in humans due to its potent androgenic effects and potential for severe side effects.
Mechanism of Action[edit]
Mibolerone works by binding to the androgen receptor, which leads to the activation of androgenic pathways. This results in the suppression of the hypothalamic-pituitary-gonadal axis, thereby preventing the release of gonadotropins and inhibiting ovulation.
Side Effects[edit]
The use of mibolerone can lead to several side effects, especially with prolonged use. These may include:
- Hepatotoxicity
- Virilization in female animals
- Behavioral changes
- Increased risk of cardiovascular issues
Regulation and Legal Status[edit]
Mibolerone is classified as a controlled substance in many countries due to its potent anabolic and androgenic effects. It is banned in competitive sports by organizations such as the World Anti-Doping Agency (WADA).
Related Compounds[edit]
See Also[edit]
References[edit]
External Links[edit]
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