Mibolerone

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Mibolerone structure
Mibolerone molecule ball
Miboleronesynthesis

Mibolerone is a synthetic anabolic steroid and a potent androgen that was developed in the 1960s. It is a derivative of nandrolone and is known for its strong anabolic and androgenic effects. Mibolerone is primarily used in veterinary medicine to prevent estrus (heat) in female dogs.

Chemical Structure and Properties

Mibolerone is chemically known as 7α,17α-dimethyl-19-nortestosterone. It is a 17α-alkylated derivative of nandrolone, which makes it orally active. The compound has a high affinity for the androgen receptor, contributing to its potent effects.

Medical Uses

In veterinary medicine, mibolerone is used to suppress estrus in female dogs. It is administered orally and is effective in preventing the onset of heat. The drug is not approved for use in humans due to its potent androgenic effects and potential for severe side effects.

Mechanism of Action

Mibolerone works by binding to the androgen receptor, which leads to the activation of androgenic pathways. This results in the suppression of the hypothalamic-pituitary-gonadal axis, thereby preventing the release of gonadotropins and inhibiting ovulation.

Side Effects

The use of mibolerone can lead to several side effects, especially with prolonged use. These may include:

Regulation and Legal Status

Mibolerone is classified as a controlled substance in many countries due to its potent anabolic and androgenic effects. It is banned in competitive sports by organizations such as the World Anti-Doping Agency (WADA).

Related Compounds

See Also

References



External Links

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  • Mibolerone structure

  • Mibolerone molecule ball

  • Mibolerone synthesis

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Contributors: Prab R. Tumpati, MD