Canrenone
Canrenone (pronounced: kan-REN-own) is a steroidal anti-mineralocorticoid of the spirolactone group that is used as a diuretic in Europe, including in Italy and Belgium. It is an active metabolite of spironolactone, and is believed to be partially responsible for its effects.
Etymology
The term "Canrenone" is derived from the chemical structure of the compound. The prefix "can" is derived from the Latin word "canalis" which means channel. The suffix "renone" is derived from the Latin word "ren" which means kidney. This is in reference to the drug's action on the renal (kidney) channels.
Pharmacology
Canrenone works by antagonizing the aldosterone receptor. Aldosterone is a hormone that promotes the retention of sodium and water, while promoting the excretion of potassium in the kidneys. By blocking the action of aldosterone, canrenone promotes the excretion of sodium and water, while retaining potassium. This makes it useful in the treatment of conditions where there is too much fluid in the body, such as congestive heart failure, liver cirrhosis, and kidney disease.
Related Terms
- Spironolactone: A medication that is metabolized into canrenone in the body.
- Aldosterone: A hormone that canrenone works to block.
- Diuretic: A type of medication that promotes the production of urine. Canrenone is a type of diuretic.
- Congestive heart failure: A condition that can be treated with canrenone.
- Liver cirrhosis: A condition that can be treated with canrenone.
- Kidney disease: A condition that can be treated with canrenone.
External links
- Medical encyclopedia article on Canrenone
- Wikipedia's article - Canrenone
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