Mepitiostane
Synthetic anabolic-androgenic steroid
Mepitiostane | |
---|---|
![]() | |
INN | |
Drug class | |
Routes of administration | |
Pregnancy category | |
Bioavailability | |
Metabolism | |
Elimination half-life | |
Excretion | |
Legal status | |
CAS Number | |
PubChem | |
DrugBank | |
ChemSpider | |
KEGG |
Mepitiostane is a synthetic anabolic-androgenic steroid (AAS) and a derivative of dihydrotestosterone (DHT). It is known for its use in the treatment of breast cancer in women. Mepitiostane is the 17α-methylated derivative of epitiostanol, which is also an AAS used for similar purposes.
Chemical Structure and Properties
Mepitiostane is chemically characterized by the presence of a 17α-methyl group, which distinguishes it from its parent compound, epitiostanol. This modification enhances its oral bioavailability, making it more effective when administered orally compared to non-17α-alkylated steroids.
The compound is a 17α-alkylated anabolic steroid, which means it has been modified to resist breakdown by the liver, allowing it to be effective when taken orally. However, this modification also increases the potential for hepatotoxicity, a common concern with 17α-alkylated steroids.
Pharmacology
Mepitiostane functions primarily as an androgen receptor agonist. It binds to androgen receptors in target tissues, promoting anabolic effects such as increased protein synthesis and muscle growth. Its androgenic effects are relatively mild compared to its anabolic effects, which makes it suitable for use in women, particularly in the treatment of breast cancer.
Medical Uses
Mepitiostane has been used in the treatment of breast cancer due to its ability to antagonize the effects of estrogen, a hormone that can promote the growth of certain types of breast cancer cells. By binding to androgen receptors, mepitiostane can inhibit the proliferation of these cancer cells.
Side Effects
As with other anabolic steroids, mepitiostane can cause a range of side effects. These may include virilization in women, such as deepening of the voice, increased body hair, and other masculinizing effects. Due to its 17α-alkylation, there is also a risk of liver damage with prolonged use.
Related Compounds
Mepitiostane is closely related to epitiostanol, which is its non-17α-alkylated counterpart. Both compounds share similar mechanisms of action and therapeutic uses, but mepitiostane's oral bioavailability makes it more convenient for certain treatment regimens.
Related Pages
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD