N-Desmethylapalutamide

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N-Desmethylapalutamide (pronunciation: N-Des-meth-yl-ap-alu-ta-mide) is a biologically active metabolite of Apalutamide, a nonsteroidal antiandrogen (NSAA) used in the treatment of prostate cancer.

Etymology

The term "N-Desmethylapalutamide" is derived from the parent compound, Apalutamide, with the prefix "N-Desmethyl" indicating the removal of a methyl group from the nitrogen atom of the parent compound.

Pharmacology

N-Desmethylapalutamide is primarily formed in the liver by the enzyme CYP3A4. It has similar antiandrogenic activity to Apalutamide and contributes significantly to the overall effect of the drug. It works by binding to the androgen receptor and preventing its activation by androgens, thereby inhibiting the growth of prostate cancer cells.

Clinical Use

N-Desmethylapalutamide, along with Apalutamide, is used in the treatment of non-metastatic castration-resistant prostate cancer. It is also being investigated for use in other types of cancer.

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