Testosterone propionate/testosterone phenylpropionate/testosterone isocaproate/testosterone decanoate
== Testosterone propionate/testosterone phenylpropionate/testosterone isocaproate/testosterone decanoate ==
Testosterone propionate/testosterone phenylpropionate/testosterone isocaproate/testosterone decanoate is a combination of four testosterone esters. This combination is used in androgen replacement therapy for males with conditions associated with a deficiency or absence of endogenous testosterone. The mixture is designed to provide a sustained release of testosterone into the bloodstream.
Components
The combination includes the following testosterone esters:
- Testosterone propionate: A short-acting ester with a half-life of approximately 2-3 days.
- Testosterone phenylpropionate: An intermediate-acting ester with a half-life of approximately 4-5 days.
- Testosterone isocaproate: An intermediate-acting ester with a half-life of approximately 7-9 days.
- Testosterone decanoate: A long-acting ester with a half-life of approximately 15-16 days.
Mechanism of Action
Testosterone esters are prodrugs of testosterone. They are converted into testosterone in the body, which then exerts its effects by binding to the androgen receptor. This binding influences the transcription of specific genes, leading to the development and maintenance of male secondary sexual characteristics and other androgenic effects.
Medical Uses
This combination is primarily used in the treatment of:
- Hypogonadism in males
- Delayed puberty in males
- Hormone therapy for transgender men
Administration
The combination is typically administered via intramuscular injection. The frequency of administration depends on the specific formulation and the individual patient's needs, but it is generally given every 1 to 4 weeks.
Side Effects
Common side effects include:
- Acne
- Gynecomastia
- Increased red blood cell count
- Injection site reactions
Serious side effects may include:
Contraindications
This combination is contraindicated in individuals with:
- Known or suspected prostate cancer
- Known or suspected breast cancer in males
- Severe cardiovascular disease
- Severe liver disease
Related Pages
- Testosterone
- Androgen replacement therapy
- Hypogonadism
- Testosterone propionate
- Testosterone phenylpropionate
- Testosterone isocaproate
- Testosterone decanoate
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