Tiomesterone
Tiomesterone
Tiomesterone is a synthetic anabolic steroid and a derivative of testosterone. It is known for its potent androgenic and anabolic effects. Tiomesterone was developed in the 1960s and has been studied for its potential use in androgen replacement therapy and other medical applications.
Chemical Properties
Tiomesterone is classified as a 17_-alkylated anabolic steroid, which means it has been modified at the 17th carbon position to enhance its oral bioavailability. This modification also increases its resistance to hepatic metabolism, allowing it to remain active in the body for a longer duration compared to non-alkylated steroids.
Mechanism of Action
Tiomesterone exerts its effects by binding to the androgen receptor, which is present in various tissues throughout the body. Upon binding, it activates the receptor, leading to increased protein synthesis and muscle growth. This mechanism is similar to that of other anabolic steroids, which promote the development of skeletal muscle and other androgen-dependent tissues.
Medical Uses
While Tiomesterone has been studied for its potential therapeutic applications, it is not widely used in clinical practice. Its primary use has been in research settings to understand the effects of anabolic steroids on muscle growth and androgenic activity. Potential medical uses include treatment of conditions such as hypogonadism, muscle wasting, and certain types of anemia.
Side Effects
As with other anabolic steroids, Tiomesterone can cause a range of side effects, particularly when used in high doses or for extended periods. Common side effects include:
- Hepatotoxicity due to its 17_-alkylated structure
- Gynecomastia
- Acne and oily skin
- Hair loss
- Mood changes
- Testicular atrophy
Legal Status
Tiomesterone, like many anabolic steroids, is classified as a controlled substance in many countries. Its use is restricted to specific medical conditions and is subject to regulation to prevent abuse and non-medical use.
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