Corticotropin-releasing hormone
Corticotropin-releasing hormone
Corticotropin-releasing hormone (pronounced as kor-ti-ko-tro-pin re-lea-sing hor-mone), also known as CRH or corticotropin-releasing factor (CRF), is a peptide hormone and neurotransmitter involved in the stress response. Its primary function is the stimulation of the pituitary synthesis of ACTH, as part of the HPA axis.
Etymology
The term "corticotropin-releasing hormone" is derived from its role in the body. "Cortico-" refers to the adrenal cortex, the primary site of action for the hormone. "-tropin" is derived from the Greek "tropos", meaning "turn" or "change", and is used in the names of hormones that stimulate other glands. "Releasing hormone" indicates its function in triggering the release of another hormone, in this case, ACTH.
Function
Corticotropin-releasing hormone is produced and secreted by the paraventricular nucleus of the hypothalamus. It is released in response to various triggers such as stress, illness, or changes in light or temperature. Once released, CRH travels to the pituitary gland, where it stimulates the release of ACTH. ACTH then travels to the adrenal glands, prompting them to produce and release cortisol, a hormone that helps the body respond to stress.
Related Terms
External links
- Medical encyclopedia article on Corticotropin-releasing hormone
- Wikipedia's article - Corticotropin-releasing hormone
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