Licarbazepine

Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine.<ref name="pmid23861647">Singh RP, Asconapé JJ,

 A review of eslicarbazepine acetate for the adjunctive treatment of partial-onset epilepsy, 
 J Cent Nerv Syst Dis, 
 2011,
 Vol. 3,
 pp. 179–87,
 DOI: 10.4137/JCNSD.S4888,
 PMID: 23861647,
 PMC: 3663619,</ref> It is an active metabolite of oxcarbazepine.<ref name="pmid23861647" /><ref name="pmid22612290">Bialer M, Soares-da-Silva P, 
 Pharmacokinetics and drug interactions of eslicarbazepine acetate, 
 Epilepsia, 
 
 Vol. 53(Issue: 6),
 pp. 935–46,
 DOI: 10.1111/j.1528-1167.2012.03519.x,
 PMID: 22612290,</ref> In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate.<ref name="pmid23861647" /><ref name="pmid22612290" /> Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.<ref name="pmid23861647" /><ref name="pmid22612290" />

References

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