Encainide
Encainide
Encainide (pronounced as en-KAY-nide) is a class 1C antiarrhythmic agent that was primarily used in the treatment of cardiac arrhythmia. It was withdrawn from the market due to its proarrhythmic effects and the increased mortality among patients.
Etymology
The term 'Encainide' is derived from the chemical name N-2,6-dimethylphenyl)-2-(ethylamino)-1-propanamide. The suffix '-ide' is commonly used in the nomenclature of chemical substances.
Usage
Encainide was used to treat life-threatening ventricular arrhythmias, such as ventricular tachycardia and ventricular fibrillation. However, it was found to increase the risk of arrhythmias and was associated with a higher mortality rate, leading to its withdrawal from the market.
Mechanism of Action
Encainide works by blocking the fast inward sodium current, thereby slowing the rate of rise of the action potential and prolonging its duration. This results in a decrease in excitability and conductivity of the heart muscle, helping to restore normal rhythm.
Side Effects
Common side effects of Encainide include dizziness, nausea, vomiting, and shortness of breath. Serious side effects may include heart failure, stroke, and sudden cardiac death.
Related Terms
- Antiarrhythmic agent
- Cardiac arrhythmia
- Ventricular tachycardia
- Ventricular fibrillation
- Heart failure
- Stroke
- Sudden cardiac death
External links
- Medical encyclopedia article on Encainide
- Wikipedia's article - Encainide
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