Dendrotoxin

Dendrotoxin is a type of neurotoxin produced by certain species of venomous snakes, specifically those in the genus Dendroaspis, commonly known as mambas. These toxins are composed of proteins and have a high affinity for particular subtypes of voltage-gated potassium channels in neurons. This makes them valuable tools for isolating and studying these channels in a biological context.

Structure and Function

Dendrotoxins are small proteins that typically consist of 57-60 amino acid residues and are cross-linked by three disulfide bridges. They have a high affinity for certain types of voltage-gated potassium channels, which they bind to and block. This prevents the return of the cell to its resting state after an action potential, leading to spontaneous firing of the neurons and the symptoms of envenomation.

Clinical Significance

The primary clinical significance of dendrotoxins is in the treatment of neurological disorders. Because of their ability to selectively bind to and inhibit certain types of potassium channels, they have potential as therapeutic agents in conditions such as Alzheimer's disease, Parkinson's disease, and epilepsy. However, their use in this context is still largely experimental and further research is needed to fully understand their potential benefits and risks.

See Also

• Neurotoxin
• Venomous snake
• Voltage-gated potassium channel

References

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Dendrotoxin

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  Sequence alignment dendrotoxins

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  Dendrotoxin alpha