Levamlodipine
| Levamlodipine | |
|---|---|
| Levamlodipine.svg | |
| INN | |
| Drug class | |
| Routes of administration | Oral |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | 103129-82-4 |
| PubChem | 5282459 |
| DrugBank | DB00381 |
| ChemSpider | 4447607 |
| KEGG | D07452 |
Levamlodipine is the S-enantiomer of the calcium channel blocker amlodipine. It is used in the treatment of hypertension and angina pectoris. Levamlodipine is a more potent enantiomer compared to its counterpart, the R-enantiomer, and is responsible for the majority of the pharmacological activity of the racemic mixture of amlodipine.
Pharmacology[edit]
Levamlodipine works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle cells. This inhibition leads to a decrease in vascular resistance and myocardial oxygen demand, which helps to lower blood pressure and alleviate angina.
Clinical Use[edit]
Levamlodipine is primarily indicated for the management of hypertension and chronic stable angina. It may also be used in the treatment of vasospastic angina (Prinzmetal's angina). The drug is administered orally and is available in various dosages.
Side Effects[edit]
Common side effects of levamlodipine include edema, dizziness, flushing, and palpitations. Less common but more serious side effects can include hypotension, myocardial infarction, and hepatic dysfunction.
Comparison with Amlodipine[edit]
While both levamlodipine and amlodipine are used to treat similar conditions, levamlodipine is often preferred due to its higher potency and potentially lower incidence of side effects. The pharmacokinetics of levamlodipine allow for effective blood pressure control with a lower dose compared to the racemic mixture.
See Also[edit]
References[edit]
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