Dofetilide
Dofetilide
Dofetilide (pronounced doh-FET-ill-ide) is a type of antiarrhythmic agent used in the treatment of certain types of cardiac arrhythmia including atrial fibrillation and atrial flutter. It is classified as a class III antiarrhythmic drug, specifically blocking potassium channels in the heart to delay repolarization.
Etymology
The name 'Dofetilide' is derived from its chemical structure. It is a synthetic compound and does not have a natural source or traditional etymology.
Pharmacology
Dofetilide works by inhibiting the rapid component of the delayed rectifier outward potassium current (IKr) in the heart. This action prolongs the cardiac action potential duration and refractory period, which can help to restore a regular heart rhythm.
Usage
Dofetilide is used to maintain normal sinus rhythm in patients with atrial fibrillation or atrial flutter. It is also used to convert these arrhythmias to normal sinus rhythm in situations where direct current cardioversion is not appropriate or has failed.
Side Effects
Common side effects of Dofetilide include headache, dizziness, and nausea. Serious side effects can include ventricular arrhythmia, heart failure, and pulmonary embolism.
Related Terms
- Antiarrhythmic agent
- Cardiac arrhythmia
- Atrial fibrillation
- Atrial flutter
- Potassium channels
- Cardiac action potential
- IKr
- Direct current cardioversion
- Ventricular arrhythmia
- Heart failure
- Pulmonary embolism
External links
- Medical encyclopedia article on Dofetilide
- Wikipedia's article - Dofetilide
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