Valpromide

Valpromide

Valpromide is a carboxamide derivative of valproic acid, used as an antiepileptic drug. It is an active metabolite of valproic acid, and its pharmacological effects are thought to be largely due to its conversion to that substance. Valpromide is used primarily in Europe and is not available in the United States.

Pharmacology

Valpromide works by increasing the amount of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter, a chemical that nerves in the brain use to send messages to one another. It is thought that one of the ways that valpromide might control seizures is by increasing the effect of GABA in the brain.

Medical Uses

Valpromide is used to treat various types of seizure disorders. It is not used as a first-line treatment, but rather is used when other treatments have failed to control seizures. It is also used in the treatment of bipolar disorder, particularly in Europe.

Side Effects

Like all medications, valpromide can cause side effects. The most common side effects include nausea, vomiting, dizziness, and tiredness. More serious side effects can include liver damage, pancreatitis, and blood disorders.

Interactions

Valpromide can interact with a number of other medications, including other antiepileptic drugs, certain antidepressants, and some antibiotics. It is important for patients to tell their doctor about all the medications they are taking, including over-the-counter drugs and dietary supplements.

See Also

• Valproic acid
• Carboxamide
• Antiepileptic drug
• Gamma-aminobutyric acid

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