Ranolazine
Ranolazine
Ranolazine (pronounced as /rænˈoʊləziːn/) is a pharmaceutical drug used primarily for the treatment of angina pectoris (chest pain). It is classified under the drug class of antianginal agents.
Etymology
The term "Ranolazine" is derived from a combination of random syllables, a common practice in the naming of pharmaceutical drugs. The exact etymology is not known.
Usage
Ranolazine is used to treat chronic angina and may be used as part of a combination therapy. It works by improving blood flow to help the heart work more efficiently. Ranolazine does not completely prevent chest pain, rather it reduces the frequency of the angina episodes and increases exercise capacity.
Mechanism of Action
Ranolazine inhibits the late phase of inward sodium channel current thereby reducing the intracellular sodium concentration. This, in turn, decreases the calcium overload in the cell by limiting the activation of the sodium-calcium exchanger. The reduction in intracellular calcium overload results in a decrease in tension and oxygen consumption in the cardiac muscle, thereby reducing the symptoms of angina.
Side Effects
Common side effects of Ranolazine include dizziness, headache, constipation, and nausea. Serious side effects may include QT prolongation, which can lead to serious irregular heartbeats.
Related Terms
External links
- Medical encyclopedia article on Ranolazine
- Wikipedia's article - Ranolazine
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