Ethoxzolamide

From WikiMD's medical encyclopedia

A carbonic anhydrase inhibitor used in the treatment of glaucoma and other conditions


Ethoxzolamide

Chemical synthesis of Ethoxzolamide

Ethoxzolamide is a sulfonamide and a carbonic anhydrase inhibitor that is used primarily in the treatment of glaucoma. It is also used in the management of certain other medical conditions such as epilepsy, altitude sickness, and periodic paralysis.

Mechanism of Action

Ethoxzolamide works by inhibiting the enzyme carbonic anhydrase, which is found in many tissues of the body, including the eye, kidney, and central nervous system. By inhibiting this enzyme, ethoxzolamide reduces the production of aqueous humor in the eye, thereby decreasing intraocular pressure, which is beneficial in the treatment of glaucoma.

Medical Uses

Ethoxzolamide is primarily used in the treatment of:

Side Effects

Common side effects of ethoxzolamide include:

Serious side effects may include electrolyte imbalance, metabolic acidosis, and allergic reactions.

Synthesis

The synthesis of ethoxzolamide involves the reaction of 2-amino-5-ethyl-1,3,4-thiadiazole with sulfonyl chloride to form the sulfonamide linkage. The detailed chemical synthesis is depicted in the accompanying diagram.

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Contributors: Prab R. Tumpati, MD