Bedaquiline
Bedaquiline
Bedaquiline (pronounced: bed-a-kwil-ine) is an antibiotic medication used in the treatment of tuberculosis. It is specifically used for multi-drug-resistant tuberculosis when other treatments are not sufficient. It is taken by mouth.
Etymology
The name "Bedaquiline" is derived from the chemical structure of the drug, which is a diarylquinoline. The "beda" part of the name is a reference to the two "aryl" groups in the structure, and the "quiline" part refers to the quinoline component.
Usage
Bedaquiline is used in combination with other antibacterial drugs to treat adults with multi-drug resistant tuberculosis (MDR-TB) when an effective treatment regimen cannot otherwise be provided. It is not recommended for use in patients with latent infection due to Mycobacterium tuberculosis.
Side Effects
Common side effects include nausea, joint pain, and headache. Serious side effects may include QT prolongation, liver dysfunction, and an increased risk of death.
Mechanism of Action
Bedaquiline works by inhibiting the ATP synthase of mycobacteria, an enzyme essential for energy production in Mycobacterium tuberculosis, the bacterium that causes tuberculosis.
History
Bedaquiline was approved for medical use in the United States in 2012. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.
See Also
External links
- Medical encyclopedia article on Bedaquiline
- Wikipedia's article - Bedaquiline
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