Riodipine
Riodipine is a calcium channel blocker used in the treatment of hypertension. It belongs to the dihydropyridine class of calcium channel blockers, which also includes drugs like amlodipine, nifedipine, and felodipine. Riodipine works by relaxing the muscles of your heart and blood vessels.
Mechanism of Action[edit]
Riodipine, like other calcium channel blockers, works by blocking calcium from entering cells of the heart and blood vessel walls, resulting in lower blood pressure. It does this by binding to L-type calcium channels located on the vascular smooth muscle, cardiac myocytes, and cardiac nodal tissue (SA and AV nodes). This decreases intracellular calcium leading to a reduction in muscle contraction. In the heart, this reduces cardiac output and lowers the heart rate, an effect known as negative inotropy and chronotropy, respectively.
Indications[edit]
Riodipine is primarily used in the treatment of hypertension, or high blood pressure. It may also be used for other conditions as determined by a healthcare provider.
Side Effects[edit]
Like all medications, Riodipine can cause side effects. Common side effects include headache, dizziness, fatigue, and flushing. Less common side effects can include edema, palpitations, and rash. Serious side effects are rare but can include severe hypotension, myocardial infarction, and stroke.
Contraindications[edit]
Riodipine is contraindicated in patients with known hypersensitivity to dihydropyridine derivatives, aortic stenosis, and unstable angina. It should be used with caution in patients with heart failure.
Drug Interactions[edit]
Riodipine can interact with other medications, including beta blockers, digoxin, and cimetidine. These interactions can lead to changes in the effectiveness of the medications or increase the risk of side effects.
See Also[edit]
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