SNX-482
SNX-482 is a peptide derived from the venom of the tarantula species Hysterocrates gigas. It is a potent and selective blocker of the alpha1E subunit of the voltage-gated calcium channel.
Structure
SNX-482 is a 41-amino acid peptide with three disulfide bonds. It has a unique structural motif that includes a triple-stranded beta-sheet and a single alpha-helix.
Function
SNX-482 selectively blocks the alpha1E subunit of the voltage-gated calcium channel, which is primarily expressed in the central nervous system. This blocking action can inhibit the flow of calcium ions into cells, which can affect various cellular functions.
Clinical significance
Due to its ability to selectively block certain calcium channels, SNX-482 has potential therapeutic applications in the treatment of neuropathic pain, epilepsy, and cardiac arrhythmias. However, further research is needed to fully understand its mechanisms of action and potential side effects.
See also
References
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Contributors: Prab R. Tumpati, MD
