Falipamil

Falipamil is a calcium channel blocker that is primarily used in the treatment of hypertension and angina. It is a phenylalkylamine derivative and has similar effects to verapamil.

Pharmacology

Falipamil acts by inhibiting the influx of calcium ions into cardiac and smooth muscle cells during depolarization. This results in a decrease in myocardial contractility, heart rate, and blood pressure. It also has a direct relaxant effect on vascular smooth muscle.

Clinical Use

Falipamil is used in the treatment of hypertension and angina. It can also be used in the management of supraventricular tachycardia and to prevent migraine headaches.

Side Effects

Common side effects of falipamil include dizziness, headache, flushing, and edema. Less common side effects include bradycardia, hypotension, and constipation.

Contraindications

Falipamil is contraindicated in patients with heart block, sick sinus syndrome, and severe heart failure. It should also be used with caution in patients with liver disease or kidney disease.

Interactions

Falipamil can interact with other medications, including beta blockers, digoxin, and statins. These interactions can increase the risk of side effects and decrease the effectiveness of the medication.

See Also

• Calcium channel blocker
• Hypertension
• Angina

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