Rufinamide

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Rufinamide (pronounced roo-FIN-a-mide) is an antiepileptic drug used in the treatment of seizures associated with Lennox-Gastaut syndrome, a severe form of childhood-onset epilepsy. It is marketed under the brand name Banzel by Eisai Co. and Inovelon in Europe.

Etymology

The name "Rufinamide" is derived from its chemical structure, which is a derivative of the carboxamide group. The prefix "Rufin-" is a modification of "Rufous," which refers to the reddish-brown color of the compound, and "-amide" refers to its chemical classification.

Pharmacology

Rufinamide is a triazole derivative that is believed to stabilize the neuronal membrane by influencing the activity of sodium channels, which play a key role in the generation and spread of seizure activity in the brain.

Medical Uses

Rufinamide is used primarily for the management of seizures associated with Lennox-Gastaut syndrome. It is used in combination with other antiepileptic drugs to manage this condition.

Side Effects

Common side effects of Rufinamide include dizziness, fatigue, nausea, and diplopia. Serious side effects may include multi-organ hypersensitivity, blood disorders, and severe skin reactions.

Related Terms

External links

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