Crofelemer
Crofelemer
Crofelemer (/kroʊˈfɛlɪmər/), also known as Fulyzaq and Mytesi, is a medication used to treat diarrhea associated with HIV/AIDS on antiretroviral therapy. It is derived from the red latex of the Croton lechleri tree, commonly known as the Dragon's Blood tree.
Etymology
The name "Crofelemer" is derived from the plant it is extracted from, the Croton lechleri tree. The "-mer" suffix is common in pharmaceuticals and indicates a polymer structure.
Pharmacology
Crofelemer works by inhibiting the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) and CaCC (Calcium-activated Chloride Channel), which are chloride channels in the intestines. This action reduces the amount of water that enters the intestines, thereby reducing the frequency of diarrhea.
Usage
Crofelemer is used to treat non-infectious diarrhea in adults living with HIV/AIDS on antiretroviral therapy. It is the first anti-diarrheal medication that has been FDA-approved specifically for these patients.
Side Effects
Common side effects of Crofelemer include upper respiratory tract infection, bronchitis, cough, flatulence, and increased bilirubin levels. Patients are advised to contact their healthcare provider if they experience persistent or worsening diarrhea while taking Crofelemer.
Related Terms
External links
- Medical encyclopedia article on Crofelemer
- Wikipedia's article - Crofelemer
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