JTV-519

JTV-519

Chemical structure of JTV-519

JTV-519, also known as K201, is a pharmaceutical compound that acts as a calcium channel modulator. It is primarily studied for its potential therapeutic effects in treating cardiac arrhythmias and heart failure. JTV-519 belongs to a class of drugs known as ryanodine receptor stabilizers, which are involved in the regulation of intracellular calcium levels in cardiac muscle cells.

Mechanism of Action

JTV-519 exerts its effects by stabilizing the ryanodine receptor (RyR2) on the sarcoplasmic reticulum of cardiac myocytes. The ryanodine receptor is a crucial component in the process of excitation-contraction coupling in cardiac muscle. By stabilizing this receptor, JTV-519 helps to prevent abnormal calcium leakage from the sarcoplasmic reticulum, which can lead to cardiac arrhythmias.

Clinical Applications

JTV-519 has been investigated for its potential use in treating various cardiac conditions, including:

• Atrial fibrillation
• Ventricular tachycardia
• Heart failure

The drug's ability to modulate calcium handling in cardiac cells makes it a promising candidate for managing these conditions, which are often characterized by disrupted calcium homeostasis.

Pharmacokinetics

The pharmacokinetic profile of JTV-519 includes its absorption, distribution, metabolism, and excretion. It is important to understand these parameters to optimize its therapeutic use and minimize potential side effects.

Research and Development

Ongoing research is focused on further elucidating the precise mechanisms by which JTV-519 stabilizes the ryanodine receptor and its long-term effects on cardiac function. Studies are also exploring its potential benefits in other calcium-related disorders beyond cardiac diseases.

Related Pages

• Calcium channel blocker
• Cardiac arrhythmia
• Heart failure
• Ryanodine receptor