Caroverine
Caroverine is a quinoline derivative drug with pharmacological properties that include calcium channel blocking and glutamate antagonist activities. It is primarily used in the treatment of sensorineural hearing loss and tinnitus.
Pharmacology
Caroverine acts as a non-selective calcium channel blocker and a selective glutamate antagonist. It inhibits the influx of calcium ions into cells, which is a crucial process for the transmission of nerve impulses. By blocking this process, caroverine can help to reduce the over-excitation of nerve cells that can lead to conditions such as tinnitus.
As a glutamate antagonist, caroverine inhibits the action of glutamate, a neurotransmitter that plays a key role in neural activation. This action can help to reduce the symptoms of conditions such as sensorineural hearing loss, which is often caused by over-excitation of the auditory nerves.
Clinical Uses
Caroverine is primarily used in the treatment of sensorineural hearing loss and tinnitus. Sensorineural hearing loss is a type of hearing loss that results from damage to the inner ear or the nerve pathways from the inner ear to the brain. Tinnitus is a condition characterized by the perception of noise or ringing in the ears, which is often caused by damage to the inner ear.
In clinical trials, caroverine has been shown to improve symptoms in patients with these conditions. However, further research is needed to fully understand the drug's efficacy and safety profile.
Side Effects
Like all drugs, caroverine can cause side effects. These may include nausea, dizziness, and headache. In rare cases, serious side effects such as hypotension (low blood pressure) and bradycardia (slow heart rate) may occur. Patients should be monitored closely for these side effects during treatment with caroverine.
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