Valproate pivoxil
Valproate Pivoxil[edit]
Valproate pivoxil is a prodrug of valproic acid, which is used primarily in the treatment of epilepsy and bipolar disorder. It is an esterified form of valproic acid, designed to improve the pharmacokinetic properties of the drug, such as its absorption and bioavailability.
Pharmacology[edit]
Valproate pivoxil is absorbed in the gastrointestinal tract and is then hydrolyzed to release the active compound, valproic acid. This conversion allows for a more controlled release and absorption of the medication, potentially reducing the frequency of dosing and improving patient compliance.
Mechanism of Action[edit]
Valproic acid, the active form of valproate pivoxil, works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter that helps to calm neuronal activity, which is beneficial in conditions characterized by excessive neuronal firing, such as epilepsy.
Clinical Uses[edit]
Valproate pivoxil is used in the management of various types of seizures, including absence seizures, tonic-clonic seizures, and myoclonic seizures. It is also used in the treatment of bipolar disorder, particularly in the management of manic episodes.
Side Effects[edit]
Common side effects of valproate pivoxil include nausea, vomiting, drowsiness, and dizziness. More serious side effects can include hepatotoxicity, pancreatitis, and teratogenicity. Patients taking valproate pivoxil should be monitored for liver function and other potential adverse effects.
Related pages[edit]
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
