Valproate pivoxil

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An article about the medication Valproate pivoxil


Valproate Pivoxil

Chemical structure of Valproate pivoxil

Valproate pivoxil is a prodrug of valproic acid, which is used primarily in the treatment of epilepsy and bipolar disorder. It is an esterified form of valproic acid, designed to improve the pharmacokinetic properties of the drug, such as its absorption and bioavailability.

Pharmacology

Valproate pivoxil is absorbed in the gastrointestinal tract and is then hydrolyzed to release the active compound, valproic acid. This conversion allows for a more controlled release and absorption of the medication, potentially reducing the frequency of dosing and improving patient compliance.

Mechanism of Action

Valproic acid, the active form of valproate pivoxil, works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter that helps to calm neuronal activity, which is beneficial in conditions characterized by excessive neuronal firing, such as epilepsy.

Clinical Uses

Valproate pivoxil is used in the management of various types of seizures, including absence seizures, tonic-clonic seizures, and myoclonic seizures. It is also used in the treatment of bipolar disorder, particularly in the management of manic episodes.

Side Effects

Common side effects of valproate pivoxil include nausea, vomiting, drowsiness, and dizziness. More serious side effects can include hepatotoxicity, pancreatitis, and teratogenicity. Patients taking valproate pivoxil should be monitored for liver function and other potential adverse effects.

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Contributors: Prab R. Tumpati, MD