Valproate pivoxil
An article about the medication Valproate pivoxil
Valproate Pivoxil
Valproate pivoxil is a prodrug of valproic acid, which is used primarily in the treatment of epilepsy and bipolar disorder. It is an esterified form of valproic acid, designed to improve the pharmacokinetic properties of the drug, such as its absorption and bioavailability.
Pharmacology
Valproate pivoxil is absorbed in the gastrointestinal tract and is then hydrolyzed to release the active compound, valproic acid. This conversion allows for a more controlled release and absorption of the medication, potentially reducing the frequency of dosing and improving patient compliance.
Mechanism of Action
Valproic acid, the active form of valproate pivoxil, works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter that helps to calm neuronal activity, which is beneficial in conditions characterized by excessive neuronal firing, such as epilepsy.
Clinical Uses
Valproate pivoxil is used in the management of various types of seizures, including absence seizures, tonic-clonic seizures, and myoclonic seizures. It is also used in the treatment of bipolar disorder, particularly in the management of manic episodes.
Side Effects
Common side effects of valproate pivoxil include nausea, vomiting, drowsiness, and dizziness. More serious side effects can include hepatotoxicity, pancreatitis, and teratogenicity. Patients taking valproate pivoxil should be monitored for liver function and other potential adverse effects.
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