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| An '''opioid''' is any agent that binds to [[opioid receptor]]s, found principally in the [[central nervous system]] and [[gastrointestinal tract]]. There are four broad classes of opioids: [[endogenous]] opioid [[peptide]]s, produced in the body; [[opium]] [[alkaloid|alkaloids]], such as [[morphine]] (the prototypical opioid) and [[codeine]]; semi-synthetic opioids such as [[heroin]] and [[oxycodone]]; and fully synthetic opioids such as [[pethidine]] and [[methadone]] that have structures unrelated to the opium alkaloids.
| | [[File:Morphin - Morphine.svg|thumb|right|Chemical structure of morphine, the prototypical natural opioid]] |
| | [[File:Opioid dependence.webm|thumb|left|Animation explaining opioid dependence]] |
| | [[File:Opiates v opioids.png|thumb|right|Diagram distinguishing between opiates (naturally derived) and opioids (including synthetic and semi-synthetic)]] |
| | [[File:Morphine structure.svg|thumb|left|Detailed molecular structure of morphine]] |
| | [[File:INTA.svg|thumb|right|INTERNATIONAL NARCOTICS CONTROL BOARD emblem related to opioid regulation]] |
| | [[File:Raw opium.jpg|thumb|left|Photograph of raw opium, the natural source of opiate alkaloids]] |
| | [[File:US timeline. Prescription opioid pain reliever deaths.jpg|thumb|right|Timeline of prescription opioid painkiller-related deaths in the U.S.]] |
| | [[File:Adrenorphin slim.svg|thumb|left|Structure of adrenorphin, an endogenous opioid peptide]] |
| | [[File:Amidorphin.svg|thumb|right|Chemical structure of amidorphin, a naturally occurring opioid]] |
| | [[File:Bovine β-casomorphin 7.svg|thumb|left|Structure of bovine β-casomorphin-7, a food-derived opioid peptide]] |
| | [[File:2-D-Alanine-5-D-leucine-enkephalin.png|thumb|right|Chemical structure of synthetic enkephalin analogue: D-Ala2-D-Leu5 enkephalin]] |
| | [[File:DAMGO.svg|thumb|left|DAMGO, a selective μ-opioid receptor agonist used in research]] |
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| Although the term '''''[[opiate]]''''' is often used as a synonym for ''opioid'', it is more properly limited to the natural opium alkaloids and the semi-synthetics derived from them.
| | '''Opioids''' are a class of drugs that bind to [[opioid receptors]] in the [[central nervous system]], [[peripheral nervous system]], and [[gastrointestinal tract]] to produce a range of effects including analgesia (pain relief), euphoria, sedation, and respiratory depression. |
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| == Pharmacology == | | == Terminology == |
| | While often used interchangeably, the term '''[[opiate]]''' technically refers only to the naturally occurring alkaloids derived from [[opium]] (e.g., [[morphine]], [[codeine]]), whereas '''opioid''' includes all compounds—natural, semi-synthetic (e.g., [[heroin]], [[oxycodone]]), and fully synthetic (e.g., [[fentanyl]], [[methadone]])—that act on opioid receptors. |
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| ''Main article: [[opioid receptor]]'' | | == Classification == |
| | Opioids are categorized into: |
| | * '''Endogenous peptides''': Naturally produced in the body (e.g., [[endorphin]]s, [[enkephalin]]s) |
| | * '''Natural opiates''': Derived directly from the opium poppy (e.g., morphine, codeine) |
| | * '''Semi-synthetic opioids''': Chemically modified natural opiates (e.g., oxycodone, heroin) |
| | * '''Synthetic opioids''': Fully synthetic compounds (e.g., fentanyl, methadone) |
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| Opioids bind to specific opioid receptors in the central nervous system and in other tissues. There are at least four major classes of [[opioid receptor]]s: μ, κ, δ and possibly σ. In addition, there are two subtypes of μ receptor: μ<sub>1</sub> and μ<sub>2</sub>.These are all [[G-protein coupled receptor]]s acting on [[GABA]]ergic [[neurotransmission]]. The [[pharmacodynamic]] response to an opioid depends on which receptor it binds, its affinity for that receptor, and whether the opioid is an [[agonist]] or an [[antagonist]]. For example, the [[supraspinal]] analgesic properties of the opioid agonist [[morphine]] are mediated by activation of the μ<sub>1</sub> receptor, respiratory depression and physical dependence (dependency) by the μ<sub>2</sub> receptor, and sedation and spinal analgesia by the κ receptor.
| | == Pharmacology == |
| | | '''Main article: [[Opioid receptor]]''' |
| ===Overdose===
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| Opioid [[overdose]] can be rapidly reversed with an opioid antagonist such as [[naloxone]] or [[naltrexone]]. These [[competitive antagonist]]s bind to the opioid receptors with higher affinity than agonists but do not activate the receptors. This displaces the agonist, attenuating and/or reversing the agonist effects. However, the [[elimination half-life]] of naloxone can be shorter than that of the opioid itself, so repeat dosing or continuous infusion may be required.
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| ===Tolerance, Dependence, and Addiction===
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| ''[[Drug tolerance|Tolerance]]'' is the tendency of the body to adapt to the presence of opioids; this adaptation makes it necessary to use ever-increasing doses of opioids in order to achieve the same effects. Tolerance is more pronounced for some effects than for others. | |
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| ''[[Drug dependence|Dependence]]'' is the tendency of the body to manifest a characteristic and unpleasant ''[[withdrawal|withdrawal syndrome]]'' if regular doses of opioids are abruptly discontinued after tolerance has developed.
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| ''[[Drug addiction|Addiction]]'' is a psychological attachment to certain effects of opioids (such as the euphoria that many people experience when the drugs are taken in sufficiently large doses) that drives some people to take the drugs even when they are not medically necessary, and even when their use of the drugs becomes self-destructive. Dependency and the unpleasantness of withdrawal can work to maintain addiction, although they do not cause it.
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| All persons receiving opioids for any reason will develop some degree of tolerance and dependence over time. Some people will also develop addiction. Addiction is much more common in persons taking opioids purely for non-medical reasons (such as recreation); it rarely develops in persons who are taking opioids under medical supervision for legitimate therapeutic purposes (such as pain management), particularly when the dosage used is too low to produce any feeling of euphoria.
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| The phenomena of tolerance and dependency, combined with the addictive potential presented by some effects of opioids (such as euphoria), make these drugs prime candidates for [[drug abuse]]. This is why the medical and especially the recreational (and usually illicit) use of opioids are so controversial. Unfortunately, as previously mentioned, opioids remain the most effective analgesics available, and so there are very strong arguments for their continued use, at least in medicine.
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| Of note, current nomenclature within the field of Psychiatry (see [[DSM-IV]]) is to use the term "Dependence" to refer to the condition of "Addiction" as defined above. As a result, a psychiatric diagnosis of opioid dependence does not imply that a withdrawal syndrome is imminent if opioids are discontinued, though such a situation could be present. This nomenclature is being reconsidered for DSM-V, expected to be published in 2011.
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| == Uses ==
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| === Clinical use ===
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| Opioids are widely used in medicine as strong [[analgesic|analgesics]] (pain relievers). Despite extensive research, no other analgesics have yet been found that are more effective for severe pain. One of the advantages of opioids is that there is no upper limit to the dosage and the achievable pain relief as long as the dose is increased gradually to allow tolerance to develop to adverse effects (especially respiratory depression).
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| Opioids have long been used to treat acute pain (such as post-operative pain). They have also found to be invaluable in [[palliative care]] to alleviate the severe, chronic, disabling pain of terminal conditions such as [[cancer]]. Very high doses are often required in palliation to improve the patients' terminal quality-of-life.
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| In recent years there has been an increased use of opioids in the management of non-malignant [[chronic pain]]. While this trend is still somewhat controversial in some circles, due to issues of [[drug addiction|dependence]], the emerging medical consensus is that most chronic pain patients can safely use opioids for years with a minimal risk of addiction or [[toxicity]] and that the overall increase in quality of life outweighs any adverse effects of opioid use.
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| As recently as the early [[20th century]], opioids were administered by doctors to treat severe depression and other [[psychiatric disorder]]s. The practice was discontinued because of the [[drug addiction|addictive]] potential of opioids. In recent decades, researchers have experimented with mixed opioid agonist/antagonists such as [[buprenorphine]] for the treatment of depression and other psychiatric disorders, encouraged by the decreased liability toward [[abuse]] of and [[dependence]] on these compounds, compared with full opioid agonists.
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| ====United States====
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| The sole clinical indications for opioids in the US, according to ''Drug Facts and Comparisons,'' 2005, are
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| * [[Analgesia]] and [[anesthesia]]
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| * Cough (codeine and hydrocodone only)
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| * Diarrhea (opium only)
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| * Anxiety due to [[dyspnoea|shortness of breath]] (oxymorphone only)
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| * Detoxification ([[methadone]] only)
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| <!-- IF YOU ARE THINKING ABOUT ALTERING this paragraph, first read the relevant citations, starting at http://en.wikipedia.org/wiki/Talk:Opioid#senile_dementia.2C_geriatric_depression.2C_chemotherapy.2C_terminal_diagnosis. Also read about Verifiability in Wikipedia at http://www.netshaq.com/cgiproxy/nph-proxy.cgi/011100A/http/en.wikipedia.org/wiki/Wikipedia:Verifiability.
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| -->Opioids are prohibited for psychological relief (with the narrow exception of anxiety due to shortness of breath), despite their extensively reported psychological benefits. The prohibition has no therapeutic basis; its basis is fear of addiction and diversion. The prohibition allows no exceptions, even when opioids might be especially effective and when the possibility of addiction or diversion is very low — for example, in the treatment of senile dementia, geriatric depression, and psychological distress due to chemotherapy or terminal diagnosis.
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| === Recreational use and abuse ===
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| Most opioids produce [[euphoria]] in many people when ingested orally, intravenously, subcutaneously, rectally, through the nasal membranes, or when smoked. Recreational use and abuse of opioids usually is motivated by a desire to experience this euphoria, and it can easily lead to addiction. Tolerance to euphoria develops rapidly; a regular user may require significantly higher and higher dosages of the substance in order to achieve the desired effect. Opioids' ability to block pain, both physical and emotional, can also encourage abuse and addiction.
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| Typically, persons taking opioids under medical supervision for the usual clinical purposes (such as pain management) are much less likely to develop addictions or patterns of abuse than those who begin using the drug specifically for its other effects such as induction of euphoria. It is unclear whether or not anti-dysphoric use (for example, to counter anxiety or depression) encourages addiction.
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| ==== History ====
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| Non-clinical use and off-label clinical use were criminalized in the USA by the [[Harrison Narcotics Tax Act]] of [[1914]], and by other laws worldwide. Since then, nearly all non-clinical use and off-label clinical use of opioids has been rated zero on the scale of approval of nearly every social institution. (However, in UK the 1926 report of the Departmental Committee on Morphine and Heroin Addiction under the Chairmanship of the President of the Royal College of Physicians reasserted medical control and established the "British system" of control — which lasted until the 1960s; in the US the Controlled Substances Act of 1970 markedly relaxed the harshness of the Harrison Act.)
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| Before the twentieth century, institutional approval was often higher, even in Europe and America. In some cultures, approval of opioids was significantly higher than approval of alcohol.
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| Cultures in which institutions have approved non-clinical use tend to be cultures that used milder opioids—for example, in pursuit of "the nod" of Asian opium dens, a [[daydream|daydreaming]] oscillation between drowsiness and attentiveness—rather than opioids such as [[heroin]] that generate a rush of excitement.
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| Today those who approve of at least some non-clinical use claim that opioids are not more addictive than alcohol; that opioids do not cause the physical damage that alcohol does (cirrhosis, domestic violence, etc.); and that approval of opioids in those cultures that approved them was earned by abuse rates well below those associated with alcohol.
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| For example, Andrew Weil says in ''From Chocolate to Morphine: Understanding Mind-Active Drugs'' that tolerance to and withdrawal from opioids is “less hazardous than [tolerance to and] withdrawal from sedative-hypnotics. … People can take opium and opiates every day for years and remain in good health, provided they keep up good habits of hygiene and nutrition. There are many documented cases of opium and morphine addicts who, despite lifelong, heavy habits, survived to ripe old ages, remaining healthy to the end. … The worst medical effect of regular opiate use is severe and chronic constipation.”
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| Today those who approve of non-clinical use of opioids often prefer the term '''''[[recreational drug use|recreational]]''''' for such use. '''Ludibund''' has been proposed as a more neutral term, but it has not caught on, and as it merely means ''playful'', it may simply be more obscure rather than more neutral. Non-clinical occasional or light users are sometimes known as '''''[[chipper|chippers]]'''''.
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| Opponents of non-clinical use point to another of its detrimental effects: apathy (an often-mentioned attribute of the habitués of opium dens) and consequent social decay.
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| == Adverse effects ==
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| Opioids are associated with a range of adverse drug reactions - mostly associated with their pharmacological actions at opioid receptors.
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| Common adverse reactions include: nausea and vomiting, drowsiness, dizziness, headache, [[orthostatic hypotension]], itch, dry mouth, [[miosis]], urinary retention, and constipation. (Rossi, 2005)
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| Infrequent adverse reactions include: dose-related respiratory depression (see below), confusion, hallucinations, [[delirium]], [[urticaria]], [[hypothermia]], [[bradycardia]]/[[tachycardia]], ureteric or biliary spasm, muscle rigidity, myoclonus (with high doses), and flushing (due to histamine release, except fentanyl and remifentanil). (Rossi, 2005).
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| The most serious adverse reaction associated with opioid use is respiratory depression. This can occur with a single dose. Although tolerance develops rapidly, respiratory depression is the mechanism behind the fatal consequences of overdose.
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| Chronic use of opioids may result in serious [[constipation]], which may progress to [[bowel obstruction]], [[fecal impaction]], or [[paralytic ileus]]. Because these conditions may require surgical intervention, stimulant [[laxatives]] are generally given as an adjunct to prevent these complications. [[Physiological tolerance]] does not develop with regard to constipation. It should be noted that in some therapeutic regimens (such as those aimed at treating diarrhea), mild constipation is a desired effect and hence laxatives would not be given.
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| Both therapeutic and chronic use of opioids can compromise the function of the [[immune system]]. Opioids decrease the proliferation of [[macrophage]] progenitor cells and [[lymphocyte]]s, and affect cell differentiation. (Roy & Loh, 1996) Opioids may also inhibit [[leukocyte]] migration.
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| === Tolerance ===
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| [[Drug tolerance|Tolerance]] can be detected within 12-24 hours of the administration of morphine (Rang ''et al''., 2003), and similarly for some other opioid agonists. Tolerance results in the necessity for increasing the dose over time to achieve the desired clinical effect.
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| Tolerance appears to develop first to the [[analgesia|analgesic]], [[sedation|sedative]], [[emesis|emetic]], [[euphoria|euphoric]] and respiratory depressive effects of opioids. The [[miosis|miotic]] and constipating effects are more resistant to the development of tolerance. (Rang ''et al''., 2003)
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| === Dependence and withdrawal issues ===
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| Regular use of an opioid for any reason rapidly induces [[physical dependence]], characterized by a highly unpleasant withdrawal syndrome when the drug is discontinued or rapidly reduced in dosage, or when an antagonist is administered. The acute withdrawal syndrome generally consists of signs and symptoms opposite to those of the drug when initially administered: severe [[dysphoria]], anxiety, eye tearing, a [[runny nose]], [[goose bumps]], sweating, nausea, vomiting, cramps and deep pains are common. The speed and severity of withdrawal depends on the half-life of the opioid—heroin withdrawal occurs more quickly and is more severe than methadone withdrawal, but methadone withdrawal takes longer. The acute withdrawal phase is often followed by a protracted phase of depression and insomnia that can last for months.
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| Physical dependence is distinct from and does not imply psychological [[addiction]], defined as uncontrolled drug use despite harm. However, physical dependence can aggravate psychological addiction when it occurs.
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| Some patients with narcotic dependence experience recurrent episodes of severe abdominal pain and nausea leading to hospitalizations and extensive diagnostic workups over periods of months to years. The intractable nausea resolves when the pain is treated with narcotics, the patient is able to go home, but another episode recurs when the pain medication runs out.
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| Withdrawal symptoms can be minimised by slowly tapering the dose over days or weeks, sometimes after switching to a long-acting opioid such as methadone. The symptoms of opioid withdrawal can also be treated with other medications, such as clonidine for sympathetic hyperactivity and a benzodiazepine for anxiety and insomnia.
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| "Rapid detox" is a relatively new technique that uses opioid antagonists to cause acute withdrawal while the patient is under general anesthesia to eliminate the otherwise extreme discomfort. This procedure has attracted controversy due to its high cost and risk; several patients have died during the procedure. Many pain specialists think that the procedure is unnecessary, and addiction specialists criticize it for doing nothing to keep an addict from relapsing into opioid abuse after the procedure is complete. Indeed, there have been reports of addicts undergoing rapid detox with the full intention of resuming addiction as the technique drastically reduces tolerance thus reducing the cost of addiction. Rapid detox also does not alleviate the protracted withdrawal syndrome that lasts for weeks or months after the acute phase.
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| Although physical dependence is nearly universal among those who use opioids regularly, true addiction is quite rare even when large amounts of opioids are used over long periods of time to treat chronic pain under the close supervision of a doctor. This is thought to be because of the rapid development of tolerance to the euphorigenic properties of opioids; without euphoria, only the unpleasant side effects (such as bowel dysfunction) remain, so there is no motivation to take more than is needed to manage pain.
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| == Examples of opioids ==
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| === Endogenous opioids ===
| | Opioids exert their effects by binding to [[G-protein coupled receptor]]s: |
| | * '''μ (mu) receptor''': Analgesia, euphoria, respiratory depression, physical dependence |
| | * '''κ (kappa) receptor''': Spinal analgesia, sedation, dysphoria |
| | * '''δ (delta) receptor''': Analgesia and mood modulation |
| | * '''NOP receptor''': Binds [[nociceptin]], not reversed by naloxone |
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| Opioid-[[peptide]]s that are produced in the body:
| | == Clinical Use == |
| | Opioids are widely prescribed for: |
| | * Acute pain (post-operative, trauma) |
| | * Chronic pain (cancer, palliative care) |
| | * Cough suppression (codeine) |
| | * Diarrhea treatment (loperamide, diphenoxylate) |
| | * Opioid dependence treatment (methadone, buprenorphine) |
| | * Anesthesia adjuncts (fentanyl) |
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| * [[Endorphin]]s | | == Adverse Effects == |
| * [[Dynorphin]]s | | * Common: [[Constipation]], nausea, drowsiness, pruritus, [[miosis]], respiratory depression |
| * [[Enkephalin]]s
| | * Serious: [[Overdose]], [[addiction]], [[immunosuppression]], [[endocrine disruption]] |
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| [[Dynorphin]] Acts through κ-opioid receptors, and is widely
| | == Tolerance, Dependence, and Addiction == |
| distributed in the CNS, including in the [[spinal cord]] and [[hypothalamus]], including in particular the [[arcuate nucleus]] and in both [[oxytocin]] and [[vasopressin]] neurons in the [[supraoptic nucleus]].
| | * '''Tolerance''': Reduced effect over time, requiring dose escalation |
| | * '''Dependence''': Withdrawal symptoms upon cessation |
| | * '''Addiction''': Compulsive use despite harm |
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| [met]-[[enkephalin]] is widely distributed in the CNS;[met]-enkephalin is a product of the proenkephalin gene, and acts through μ and δ-opioid receptors. | | == Overdose Management == |
| | * Reversed by opioid antagonists such as: |
| | ** [[Naloxone]] (Narcan) |
| | ** [[Naltrexone]] |
| | These agents outcompete opioids at receptors without activating them. |
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| [leu]-enkephalin , also a product of the proenkephalin gene, acts through δ-opioid receptors | | == Endogenous Opioids == |
| | Produced by the body, they modulate pain, stress, and emotions. |
| | * [[Endorphins]] |
| | * [[Enkephalins]] |
| | * [[Dynorphins]] |
| | * [[Endomorphins]] |
| | * [[Nociceptin]] |
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| [[Nociceptin]], formerly known as orphanin FQ, is an opioid-related peptide, but it does not act at the classic opioid receptors and actions are not antagonised by the opioid antagonist naloxone. Nociceptin is a potent anti-analgesic. Noiceptin is widely distributed in the CNS; it is found in many regions of the hypothalamus, brainstem, forebrain, as well as in the ventral and dorsal horns of the spinal cord. Nociceptin acts at the NOP1 receptor, formerly known as ORL-1. The receptor is also widely distributed in the brain, including in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, [[amygdala]], central gray, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus, and spinal cord.
| | == Opioid Epidemic == |
| | The U.S. and several countries face an ongoing public health crisis due to overprescription and illicit use. Factors include: |
| | * Increased prescribing in the 1990s–2000s |
| | * Rise of synthetic opioids (fentanyl) |
| | * Socioeconomic and mental health components |
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| Endomorphin. Acts through μ-opioid receptors, and is more potent than other endogenous opioids at these receptors.
| | == Recreational Use == |
| | Non-medical use of opioids can cause intense euphoria, making them highly addictive. Long-term abuse leads to: |
| | * Tolerance |
| | * Physical and psychological dependence |
| | * Risk of fatal overdose |
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| [[β-endorphin]] is expressed in POMC cells in the [[arcuate nucleus]] and in a small population of neurons in the brainstem, and acts through μ-opioid receptors. β-endorphin has many effects, including on sexual behavior and appetite.β-endorphin is also secreted into the circulation from pituitary [[corticotropes]] and [[melanotropes]].
| | == History == |
| α-neoendorphin is also expressed in POMC cells in the arcuate nucleus
| | Opioids have been used since ancient times. The 20th century saw regulatory acts (e.g., Harrison Narcotics Act 1914), followed by the rise of synthetic opioids and ongoing debates over pain management vs. addiction risk. |
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| === Opium alkaloids ===
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| {{div col|colwidth=15em}}
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| [[Phenanthrene|Phenanthrenes]] naturally occurring in [[opium]]:
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| | == Examples == |
| | === Natural Alkaloids === |
| * [[Morphine]] | | * [[Morphine]] |
| * [[Codeine]] | | * [[Codeine]] |
| * [[Thebaine]] | | * [[Thebaine]] |
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| Preparations of mixed opium alkaloids, including [[papaveretum]], are still occasionally used.
| | === Semi-Synthetic === |
| | | * [[Heroin]] |
| === Semisynthetic derivatives === | |
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| * [[Diamorphine]] ([[heroin]]) | |
| * [[Oxycodone]] | | * [[Oxycodone]] |
| * [[Hydrocodone]]
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| * [[Dihydrocodeine]]
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| * [[Hydromorphone]] | | * [[Hydromorphone]] |
| * [[Oxymorphone]]
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| * [[Nicomorphine]]
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| === Synthetic opioids ===
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| ==== [[Phenylheptylamine]]s ====
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| | === Synthetic === |
| | * [[Fentanyl]] |
| * [[Methadone]] | | * [[Methadone]] |
| * [[Levo-alphacetylmethadol]] (LAAM)
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| ==== [[Phenylpiperidine]]s ====
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| * [[Pethidine]] (meperidine)
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| * [[Fentanyl]]
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| * [[Alfentanil]]
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| * [[Sufentanil]]
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| * [[Remifentanil]]
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| * [[Ketobemidone]]
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| * [[Carfentanyl]]
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| ==== [[Diphenylpropylamine]] derivatives ====
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| * [[Propoxyphene]]
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| * [[Dextropropoxyphene]]
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| * [[Dextromoramide]]
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| * [[Bezitramide]]
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| * [[Piritramide]]
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| ==== [[Benzomorphan]] derivatives ====
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| * [[Pentazocine]]
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| * [[Phenazocine]]
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| ==== [[Oripavine]] derivatives ====
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| * [[Buprenorphine]]
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| ==== [[Morphinan]] derivatives ====
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| * [[Butorphanol]]
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| * [[Nalbufine]]
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| * [[Levorphanol]]
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| * [[Levomethorphan]]
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| ==== Others ====
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| * [[Dezocine]]
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| * [[Etorphine]]
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| * [[Tilidine]]
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| * [[Tramadol]] | | * [[Tramadol]] |
| * [[Loperamide]] (used for diarrhoea, does not cross the [[blood-brain barrier]]) | | * [[Loperamide]] |
| * [[Diphenoxylate]] (used for diarrhoea, does not appreciably cross the [[blood-brain barrier]])
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| === Opioid antagonists ===
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| | === Antagonists === |
| * [[Naloxone]] | | * [[Naloxone]] |
| * [[Naltrexone]] | | * [[Naltrexone]] |
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| == See also == | | == See Also == |
| | * [[Opioid receptor]] |
| | * [[Opioid epidemic]] |
| | * [[Analgesic]] |
| | * [[Substance use disorder]] |
| | * [[Endorphins]] |
| | * [[Naloxone]] |
| | * [[Chronic pain]] |
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| * [[Psychoactive drug]]
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| * [[Immunosuppressive drug]]
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| {{div col end}}
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| == External links ==
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| * [http://www.painfoundation.org American Pain Foundation]
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| * [http://www.ampainsoc.org American Pain Society]
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| * [http://www.aapainmanage.org American Academy of Pain Management]
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| * [http://www.aaap.org American Academy of Addiction Psychiatry], professional association of psychiatrists expert in addiction treatment
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| * [http://www.poppies.org/ Poppies.org]
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| * [http://www.heroinhelper.com/ Heroin Helper]
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| * [http://opioids.com/ Future Opiods]
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| * [http://www.ampainsoc.org/advocacy/opioids.htm The use of opioids for chronic pain @ The APS]
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| * [http://www.merck.com/mmhe/sec07/ch108/ch108c.html Merck Entry on Opioids]
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| == References ==
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| * Abse, D. Wilfred, William J. Rheuban, and Salman Akhtar, “The Poppy: Therapeutic Potential in Cases of Dementia with Depression”, in ''Opioids in Mental Illness: Theories, Clinical Observations, and Treatment Possibilities'', edited by Karl Verebey, The New York Academy of Sciences, New York, New York, 1982, pp. 79ff.
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| * Berridge, Virginia, ''Opium and the People: Opiate Use in Nineteenth-Century England'', 1987.
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| * Bodkin JA, Zornberg GL, Lukas SE, Cole JO (McLean Hospital, Consolidated Department of Psychiatry, Harvard Medical School), “Buprenorphine Treatment of Refractory Depression”, ''Journal of Clinical Psychopharmacology'', February, 1995, 15(1):49-57, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7714228&query_hl=2&itool=pubmed_docsum
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| * Callaway, Enoch, Editorial [re bupenorphine for psychiatric problems], ''Biological Psychiatry'', June 15, 1996.
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| * Emrich, H. M., P. Vogt, and A. Herz (Max-Planck Institute for Psychiatry, Munich, Germany), "Possible Antidepressive Effects of Opioids: Action of Buprenorphine", in ''Opioids in Mental Illness: Theories, Clinical Observations, and Treatment Possibilities'', edited by Karl Verebey, The New York Academy of Sciences, New York, New York, 1982, p. 108.
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| * Gutstein, Howard B. and Huda Akil, “Opioid Analgesics”, in ''Goodman and Gilman’s The Pharmacological Basis of Therapeutics'', 11th Edition, 2006, edited by Brunton, Laurence L., John S. Lazo, Keith L. Parker, Iain L. O. Buxton, and Donald Blumenthal.
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| * Morgan GE, Mikhail MS, Murray MJ (2002). ''Clinical Anesthesiology'' (4 ed.). New York: McGraw-Hill. ISBN 0-07-142358-3.
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| * Rang HP, Dale MM, Ritter JM, Moore PK (2003). ''Pharmacology'' (5 ed.). Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.
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| * Reynolds, A. K. and Lowell O. Randall, ''Morphine and Allied Drugs'', 1959.
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| * Rossi S (Ed.) (2004). ''[[Australian Medicines Handbook]] 2004''. Adelaide: Australian Medicines Handbook. ISBN 0-9578521-4-2.
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| * Rossi S (Ed.) (2005). ''[[Australian Medicines Handbook]] 2005''. Adelaide: Australian Medicines Handbook. ISBN 0-9578521-9-3.
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| * Roy S, Loh HH (1996). Effects of opioids on the immune system. ''Neurochem Res'' '''21''' (11), 1375-86. PMID 8947928.
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| * Karl Verebey, editor, ''Opioids in Mental Illness: Theories, Clinical Observations, and Treatment Possibilities'', The New York Academy of Sciences, New York, New York, 1982.
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| {{stub}}
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| {{Navboxes
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| |title = Articles Related to Opioid
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| |list =
| |
| {{Antiaddictives}} | | {{Antiaddictives}} |
| {{Analgesics}} | | {{Analgesics}} |
| {{Drug use}} | | {{Drug use}} |
| {{Euphoriants}} | | {{Euphoriants}} |
| {{Neuropathic pain and fibromyalgia pharmacotherapies}}
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| {{Opioidergics}} | | {{Opioidergics}} |
| }} | | {{stub}} |
| [[Category:Opioids| ]] | | |
| | [[Category:Opioids]] |
| | [[Category:Pain management]] |
| [[Category:Morphine]] | | [[Category:Morphine]] |
| [[Category:Articles containing video clips]] | | [[Category:Analgesics]] |
| == Opioid ==
| | [[Category:Substance-related disorders]] |
| <gallery>
| | [[Category:Neurological disorders]] |
| File:Morphin - Morphine.svg|Morphin - Morphine
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| File:Opioid dependence.webm|Opioid dependence
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| File:Opiates v opioids.png|Opiates vs Opioids
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| File:Morphine structure.svg|Morphine structure
| |
| File:INTA.svg|INTA
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| File:Raw opium.jpg|Raw opium
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| File:US timeline. Prescription opioid pain reliever deaths.jpg|US timeline of prescription opioid pain reliever deaths
| |
| File:Adrenorphin slim.svg|Adrenorphin
| |
| File:Amidorphin.svg|Amidorphin
| |
| File:Bovine β-casomorphin 7.svg|Bovine β-casomorphin 7
| |
| File:2-D-Alanine-5-D-leucine-enkephalin.png|2-D-Alanine-5-D-leucine-enkephalin
| |
| File:DAMGO.svg|DAMGO
| |
| </gallery>
| |
| == Opioid ==
| |
| <gallery>
| |
| File:Morphin - Morphine.svg|Morphin - Morphine
| |
| File:Opioid dependence.webm|Opioid dependence
| |
| File:Opiates v opioids.png|Opiates vs Opioids
| |
| File:Morphine structure.svg|Morphine structure
| |
| File:INTA.svg|INTA
| |
| File:Raw opium.jpg|Raw opium
| |
| File:US timeline. Prescription opioid pain reliever deaths.jpg|US timeline of prescription opioid pain reliever deaths
| |
| File:Adrenorphin slim.svg|Adrenorphin
| |
| File:Amidorphin.svg|Amidorphin
| |
| File:Bovine β-casomorphin 7.svg|Bovine β-casomorphin 7
| |
| File:2-D-Alanine-5-D-leucine-enkephalin.png|2-D-Alanine-5-D-leucine-enkephalin
| |
| File:DAMGO.svg|DAMGO
| |
| </gallery>
| |
