Calcium carbimide

Calcium Carbimide

Citrated calcium carbimide

Calcium carbimide is a chemical compound used primarily in the treatment of alcohol dependence. It acts as an alcohol deterrent by interfering with the metabolism of alcohol, leading to unpleasant effects when alcohol is consumed.

Mechanism of Action

Calcium carbimide works by inhibiting the enzyme acetaldehyde dehydrogenase, which is responsible for the breakdown of acetaldehyde, a toxic metabolite of ethanol. When acetaldehyde dehydrogenase is inhibited, acetaldehyde accumulates in the blood, causing symptoms such as flushing, nausea, and palpitations. These symptoms are intended to deter individuals from consuming alcohol.

Clinical Use

Calcium carbimide is used as part of a comprehensive treatment program for alcohol dependence. It is typically administered orally in tablet form. The drug is most effective when combined with counseling and support groups, as it helps to reinforce the desire to abstain from alcohol.

Side Effects

Common side effects of calcium carbimide include:

• Flushing
• Nausea
• Vomiting
• Headache
• Dizziness

These side effects are more pronounced when alcohol is consumed. Patients are advised to avoid alcohol completely while taking calcium carbimide.

Contraindications

Calcium carbimide is contraindicated in individuals with:

• Severe cardiovascular disease
• Severe respiratory disease
• Hypersensitivity to the drug

Related Compounds

Calcium carbimide is similar in function to disulfiram, another alcohol deterrent. Both drugs work by inhibiting acetaldehyde dehydrogenase, but they differ in their chemical structure and pharmacokinetics.

Related Pages

• Alcohol dependence
• Disulfiram
• Acetaldehyde dehydrogenase
• Ethanol

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